Effects of Desflurane and Propofol During Lung Volume Reduction Surgery

Phase 4

Completed

• Conditions: Lung Volume Reduction Surgery
• Interventions: Drug: Propofol; Drug: Desflurane

• Registration Number: NCT04226625
• Lead Sponsor: Columbia University

Brief Summary

Patients presenting for lung volume reduction are very high risk patients and it is important they receive the best anesthetic available. This study aims to answer which is the best anesthetic for managing such cases.

Detailed Description

The anesthetic technique for lung volume reduction surgery consists of a thoracic epidural in combination with a general anesthetic. The thoracic epidural is routine for this operation and allows administration of local anesthetics and painkillers in the epidural space which results in profound pain relief in the area of surgery. The epidural is routinely used for pain control during the surgery and after the surgery when the patient is awake.

The general anesthetic used may be a volatile agent (gas for example Desflurane), which is administered through the anesthesia machine, or an intravenous anesthetic agent, which is administered into a vein through an intravenous line as a continuous infusion (example Propofol). The use of an anesthetic agent and an epidural often causes a decrease in blood pressure which is treated with medication. The investigators are comparing the two anesthetic techniques regarding their effect on blood pressure and the amount of medication needed to treat it.

Study Timeline

• Study Start: 2000-01-31
• Primary Completion: 2001-03-21
• Study Completion: 2002-03-21
• Status Verified: 2020-01
• Study First Submitted: 2020-01-08
• Study First Submitted QC: 2020-01-09
• Last Update Submitted: 2020-01-09
• Study First Posted: 2020-01-13
• Last Update Posted: 2020-01-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 18

Inclusion Criteria

• Scheduled to undergo lung volume reduction surgery (LVRS)

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Exclusion Criteria

• Does not sign a study consent form

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Propofol	Propofol	Patients will receive Propofol as an intravenous (IV) agent, which is administered into a vein through an IV line as a continuous infusion.
Desflurane	Desflurane	Patients will receive Desflurane as a gas that is administered through an anesthesia machine.

Primary Outcome Measures

Name	Time	Method
Time of discontinuation of anesthetic to tidal volume (TV) 300ml	Up to 30 minutes (during procedure)	Measured in minutes
Time of discontinuation of anesthetic to extubation	Up to 30 minutes (during procedure)	Measured in minutes
Time of discontinuation of anesthetic to eye opening	Up to 30 minutes (during procedure)	Measured in minutes

Secondary Outcome Measures

Name	Time	Method
Duration of hospital stay	Up to 1 month from procedure	Measured in days
Duration of intensive care unit (ICU) stay	Up to 1 month from procedure	Measured in days

Trial Locations

Locations (1)

Columbia University Irving Medical Center; 🇺🇸 New York, New York, United States