NL-OMON54371
Not yet recruiting
Not Applicable
ncovering Pathophysiologic Mechanisms of Treatment Resistant Depression: A comparison with non-TRD patients - UNCOVER-TRD
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- Radboud Universitair Medisch Centrum
- Enrollment
- 83
- Status
- Not yet recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •\- Males and females between 18\-70 years of age
- •\- First or recurrent episode of unipolar major depressive disorder
- •\- Treatment resistance for at least two antidepressants for the TRD group
- •\- Never or only once being treated with antidepressants without effect for the
- •non\-TRD group
Exclusion Criteria
- •\- ECT within one year prior to the current course
- •\- Current use of antidepressants, antipsychotics and mood stabilizers
- •\- Use of benzodiazepines within 24 hours before ECT
- •\- Use of anti\-inflammatory drugs for more than a week in the past month (for
- •patients included for PET\-scan only)
- •\- Use of immune suppressants (for patients included for PET\-scan only)
- •\- Presence of current or past relevant somatic disorder
- •\- Presence of comorbid bipolar disorder, schizophrenia or substance abuse
- •\- MRI\- or PET\-related exclusion criteria
- •\- ECT\-related exclusion criteria(for TRD group only)
Outcomes
Primary Outcomes
Not specified
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