Effect of long duration fasting and short duration fasting on intravascular volume status and stress hormone levels.
Not Applicable
- Conditions
- Health Condition 1: K800- Calculus of gallbladder with acutecholecystitisHealth Condition 2: K80- Cholelithiasis
- Registration Number
- CTRI/2021/02/031456
- Lead Sponsor
- ICMR THESIS GRANT
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Inclusion criteria for study participants â??
1) Age more than 18years and less than 60 years
2) ASA I/II.
3) Patients undergoing laparoscopic cholecystectomy
Exclusion Criteria
Exclusion criteria for study participants â??
1) BMI more than 30.
2) Diabetic patients.
3) Hypertensive patients.
4) Patients receiving exogenous thyroid supplements or anti-thyroid medications.
5) Pregnant females.
6) ASA grade III and IV.
7) Major blood loss during surgery.
8) Missing data on study variables.
9) Patients refusing informed consent.
10) Patients receiving medications known to interfere with hormonal response to stress.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To measure and compare the status of intravascular volume by measurement of inferior vena cava collapsibility index (IVCCI) following conventional midnight fasting and shortened fasting protocol in patients undergoing laparoscopic cholecystectomy.Timepoint: Before surgery, in the preoperative area all the patients shall undergo ultrasonography assisted measurement of Inferior vena cava collapsibility index (IVCCI).
- Secondary Outcome Measures
Name Time Method To measure and compare the levels of stress hormones (fT4, serum cortisol, C-peptide, C-reactive protein) in response to moderate stress surgeries following conventional midnight fasting and fasting recommendation of ERAS protocol in patients undergoing laparoscopic cholecystectomy.Timepoint: Venous blood samples would be drawn for the measurement of biochemical parameter and would be sent to Biochemistry department at predefined time points i.e, at 8pm on the day before surgery (one hour before the dinner), on the day of the surgery at 7am (2hours before surgery), 1 hour after the tracheal extubation and 24 hours after the surgery. All the samples shall be drawn from the anticubital vein after application of tourniquet.