The effect of bedtime dosing of antihypertensive drug with both alfa and beta sympatholytic action in high-risk obstructive sleep apnea hypertensive patients
Not Applicable
- Conditions
- hypertension with obstructive sleep apnea syndrome
- Registration Number
- JPRN-UMIN000010600
- Lead Sponsor
- Jichi Medical University School of Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 12
Inclusion Criteria
Not provided
Exclusion Criteria
Exclusion criteria as follows 1)The patients treated with anti-sympathetic nervous activation agents 2)The patients with bedtime dosing of antihypertensive drug 3)The patients with congestive heart failure (more than NYHA II) 4)The patients with malignancy 5)The patients with renal failure (serum creatinine >2.0 mg/dL) or performing hemodialysis or severe liver dysfunction 6)The patients with contraindication of these drugs 7)The patients with past history of serious side effects 8)The patients who is not given informed consent by themselves 9)The patients decided inappropriate subjects for this study by physicians
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The difference in the inhibition of BP surge during sleep between two groups.
- Secondary Outcome Measures
Name Time Method Maximum, minimum and average BP during sleep, morning BP, AHI