Effect of Nocturnal Administration of Anti-hypertensive Medications in NoN-dippers

Phase 4

Completed

• Conditions: Hypertension
• Interventions: Drug: Valsaltan, amlodipine

• Registration Number: NCT01091753
• Lead Sponsor: Yonsei University

Brief Summary

The purpose of this study is to determine the effect of nocturnal administration of Anti-hypertensive medications in Non-dippers.

Efficacy variables.

1. ECHO

2. 24hr. horter

3. IMT

4. BUN/crea, urine analysis (microalbulinuria

5. Cardio vascular event. "

Detailed Description

Not available

Study Timeline

• Study Start: 2008-03
• Primary Completion: 2009-05
• Study Completion: 2009-09
• Study First Submitted: 2010-03-23
• Study First Submitted QC: 2010-03-23
• Study First Posted: 2010-03-24
• Status Verified: 2010-10
• Last Update Submitted: 2010-10-07
• Last Update Posted: 2010-10-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 28

Inclusion Criteria

1. Essential hypertension (stage 1-2)
2. 24hr. holer : non-dipper
3. Age 18 ~70.

Exclusion Criteria

1. Any known malignant disease
2. Renal failure , creatinine >2.0mg/dl
3. Liver disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
nocturnal administration group	Valsaltan, amlodipine	-
morning administration group	Valsaltan, amlodipine	-

Primary Outcome Measures

Name	Time	Method
IMT(intima media thickness) Measure data(Sono)	36 months

Trial Locations

Locations (1)

Severance Hospital, Yonsei University College of Medicine; 🇰🇷 Seoul, Korea, Republic of