A Study on Escherichia coli isolated from extra intestinal clinical samples
Not Applicable
- Conditions
- Health Condition 1: A415- Sepsis due to other Gram-negativeorganisms
- Registration Number
- CTRI/2021/08/035531
- Lead Sponsor
- Indian Council of Medical Research
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
As per the NHSN criteria
Exclusion Criteria
1)Asymptomatic UTI
2)Pregnant woman
3)Out patients
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The expression of individual virulence genes with the focus of invasive infection will give a broader idea of the pathogenesis of E.coli infection leading to bacteremia. The true association of virulence genes with invasive infection can be better determined. <br/ ><br>The accurate MIC for combination therapy in case of carbapenem resistant E. coli tested in vitro will give a further knowledge to use the best available combination in treatment regimens in case of carbapenem resistant E. coli infection. <br/ ><br>It might also help in reducing the dosage in toxicity related to unwanted antimicrobial use.Timepoint: With in 2yrs
- Secondary Outcome Measures
Name Time Method The common phylogroup in specific disease type will be observed and its distribution among various infections will be analyzed. <br/ ><br>The true association of virulence genes with invasive infection can be better determined. <br/ ><br>This will further help to assess the necessity to extent the antimicrobial spectrum in treating MDR pathogens.Timepoint: With in 2years