The effect of Exenatide on brown adipose tissue activity and energy expenditure in healthy young me

Phase 4

Completed

Conditions: utritional and Metabolic Diseases
Metabolic disease
obesity

Registration Number: NL-OMON46200

Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 24

Inclusion Criteria

- Dutch South Asian or white Caucasian male, 20-36 years of age
- BMI * 18 and * 27 kg/m2
- Good general health

Exclusion Criteria

- BMI > 27 kg/m2 or < 18 kg/m2
- Use of medication known to influence glucose and/or lipid metabolism or brown fat activity (e.g. beta blockers)
- Any significant chronic disease
- Renal, hepatic or endocrine disease
- Smoking
- Participation in an intensive weight-loss program or vigorous exercise program during the last year before the start of the study
- Participation in > 4 research projects within the last year, participation in multiple medicinal research projects at the same time'
- Contraindications for undergoing an MRI scan:
- Presence of non-MR safe metal implants or objects in the body.
- Pacemaker, neurostimulator, hydrocephalus pump, drug pump, non-removable hearing aid, large recent tattoos.
- Claustrophobia
- Tinnitus or hyperacusis

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- The effect of Exenatide on brown adipose tissue activity (measured by 18F-FDG<br /><br>PET-CT scan and MRI scan) and validation of the MRI scan as a novel technique<br /><br>for measuring brown adipose tissue activity<br /><br>- The effect of Exenatide on energy expenditure (measured by indirect<br /><br>calorimetry)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- The effect of Exenatide on glucose- and lipid metabolism (measured in the<br /><br>blood)<br /><br>- The effect of Exenatide on fat mass (measured by bio-impedance analysis)</p><br>