Effect of Exenatide on brown adipose tissue

Phase 1

• Conditions: Healthy volunteers, intended indications: obesity and dyslipidemia; Therapeutic area: Diseases [C] - Nutritional and Metabolic Diseases [C18]

• Registration Number: EUCTR2016-000238-23-NL
• Lead Sponsor: eiden University Medical Center

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2016-07-28
• Last Update Posted: 7 May 2018

Recruitment & Eligibility

• Status: ot Recruiting
• Sex: Male
• Target Recruitment: 24

Inclusion Criteria

-Dutch South Asian or white Caucasian male, 18-30 years
-BMI = 18 and = 25 kg/m2
-Good general health

Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range 24
F.1.3 Elderly (>=65 years) no
F.1.3.1 Number of subjects for this age range

Exclusion Criteria

-BMI > 25 kg/m2 or < 18 kg/m2
-Use of medication known to influence glucose and/or lipid metabolism or brown fat activity (e.g. beta blockers)
-Any significant chronic disease
-Renal, hepatic or endocrine disease
-Smoking
-Participation in an intensive weight-loss program or vigorous exercise program during the last year before the start of the study
-Recent participation in other research projects (within the last 3 months), participation in 2 or more projects in one year
-Contraindications for undergoing an MRI scan:
-Presence of non-MR safe metal implants or objects in the body.
-Pacemaker, neurostimulator, hydrocephalus pump, drug pump, non-removable hearing aid, large recent tattoos.
-Claustrophobia
-Tinnitus or hyperacusis

Study & Design

• Study Type: Interventional clinical trial of medicinal product
• Study Design: Not specified