Cogmed Training Effect in Hypertensive Patients With Cognitive Impairment

Not Applicable

Completed

• Conditions: Hypertension
• Interventions: Other: Cogmed

• Registration Number: NCT02738034
• Lead Sponsor: University of Sao Paulo General Hospital

Brief Summary

Systemic arterial hypertension is a disease with high prevalence in several countries, including Brazil. Many studies have correlated hypertension with accelerated loss of cognitive function, especially executive functions. There is some evidence that working memory (WM) is compromised in these populations. However, some computerized training has been developed to rehabilitate the WM, and among them the investigators highlight the Cogmed. Thus, the aim of this study is to evaluate the effects of Cogmed training in the performance of WM and attention of hypertensive patients, as well as the impact of training in the structure and brain function.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2016-03-23
• Study First Submitted QC: 2016-04-13
• Study First Posted: 2016-04-14
• Study Start: 2016-08
• Primary Completion: 2020-10
• Status Verified: 2020-11
• Study Completion: 2020-12
• Last Update Submitted: 2021-11-16
• Last Update Posted: 2021-11-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 32

Inclusion Criteria

• Individuals of both genders, of any ethnicity
• Signing the consent form
• Access to computer with internet at home
• Inexperienced to computerized cognitive training
• Hypertensive pre-diagnosed
• Basic schooling of four years
• Cognitive impairment

Exclusion Criteria

• Marked functional limitation
• Cognitive limitation or serious communication
• Severe neurological and psychiatric diseases
• Stroke history, head trauma or substance abuse

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Adaptive training group	Cogmed	The intervention group will be composed of hypertensive participants with cognitive decline that will be submitted to the training program (Cogmed) for approximately 10 weeks. Across training, task difficulty was adjusted as a function of individual performance.
Active control Group	Cogmed	In the control group, hypertensive patient will be submitted to a set of online games available on the internet and previously determined. In this way, the control group will receive the same motivation, as well as will be engaged in computerized activities, in the same way as the experimental group. The difference is that these varied games do not provide any type of intense and adaptive training, at the same time as they do not stimulate any specific cognitive function.

Primary Outcome Measures

Name	Time	Method
Working memory score	10 weeks	Backward Digits Test / Letter-Number Sequencing (WAIS-III): total score (sum of right answers)

Secondary Outcome Measures

Name	Time	Method
Brain function	10 weeks	Functional magnetic resonance
Verbal memory score	10 weeks	Stories of Wechsler Memory Scale Revised - WMS R
Visual memory score	10 weeks	Rey complex figure
Executive functions score	10 weeks	Stroop test, Wisconsin Card Sorting Test, Frontal Assessment Battery and Controlled Oral Word Association Test

Trial Locations

Locations (1)

Regina Silva Paradela; 🇧🇷 Sao Paulo, São Paulo, Brazil