Blood Lactate Levels in Patients Treated With Typical or Atypical Antipsychotics
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Blood lactate levels
研究概览
简要总结
Blood lactate levels in patients receiving typical or atypical antipsychotics have not been described in the literature.
The goal of this study is to assess the dynamics of lactate levels in the blood from typical or atypical antipsychotics not confounded by prior antipsychotic treatments, the investigators conducted a prospective study of lactate levels in patients receiving antipsychotic medication. The investigators hypothesized that 6 months of treatment with haloperidol or olanzapine would result in a change in blood lactate levels and extrapyramidal side effects.
详细描述
The aim of this study was to compare the blood lactate levels in patients receiving typical or atypical antipsychotics.
Subjects included sixty patients with psychotic disorder were assigned to treatment for 6 months with haloperidol (typical antipsychotic), N=30 or olanzapine (atypical antipsychotic), N=30. Blood lactate levels, other metabolic parameters, and scores on the extrapyramidal symptom rating scale (ESRS) were assessed.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 50 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •Men aged 20 - 50 years
- •Not taking any antipsychotic medication 1 month prior to the study
- •Diagnosed psychotic disorder
排除标准
- •Tobacco use
- •Diabetes mellitus
- •Baseline lactate blood level over 2.0 mmol/L
研究组 & 干预措施
Antipsychotic treatment
Patients were not taking any medications - apart from the prescribed antipsychotic - for a period of 1 month prior to the study with psychotic relapse or newly diagnosed psychotic disorder were recruited from psychiatric inpatient and outpatient clinics of the Split Clinical Hospital.
干预措施: Haloperidol or olanzapine (Drug)
结局指标
主要结局
Blood lactate levels
时间窗: 6 months
次要结局
- Extrapyramidal side effects(6 months)