Electrocardiographic and Cardiac Magnetic Resonance Predictors of Ventricular Arrhythmias in Cardiomyopathic Patients

• Conditions: Premature Ventricular Complex

• Registration Number: NCT05078125
• Lead Sponsor: Assiut University

Brief Summary

This study aims to assess ECG changes for predicting ventricular arrhythmia in cardiomyopathic patients

Detailed Description

This study aims to assess ECG markers based on 24-hour Holter ECG recordings for predicting ventricular arrhythmia in patients with Structural Heart disease who have left ventricular dysfunction and Left Ventricular Ejection Fraction ≤40%. With special concerns to underlying structural abnormalities in cardiomyopathic patients using Cardiac Magnetic Resonance to determine ventricular function, scar distribution, and grey zone analysis

Study Timeline

• Study First Submitted: 2021-10-02
• Study First Submitted QC: 2021-10-02
• Study First Posted: 2021-10-14
• Status Verified: 2022-01
• Last Update Submitted: 2022-01-23
• Last Update Posted: 2022-01-25
• Study Start: 2022-04-01
• Primary Completion: 2022-12-31
• Study Completion: 2023-03-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 79

Inclusion Criteria

• Patients with ischemic and non-ischemic cardiomyopathy, EF < 40 %
• Patient haemodynamically stable
• Patients accept to make test

Exclusion Criteria

1. Patients with underlying arrhythmia ex heart block or atrial arrhythmia like PACs, AF.
2. Patients on arrhythmogenic drugs ex digitalis, amiodarone.
3. Patients on underlying Pacemaker device or CRT-D.
4. Patients with MI in less than 40 days
5. Patients refuse to make test .

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Twenty-four hours Holter monitoring after Magnetic Resonance Imaging	One year	24 Holter monitoring to detect PVCs burden which is defined as ≥10% of total beats