A Blinded Prospective Study on Development and Validation of the Blood Cell RNA-Based Cancer Detection
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Neoplasms
- Sponsor
- Wuhan Union Hospital, China
- Enrollment
- 5000
- Locations
- 1
- Primary Endpoint
- Accuracy of TOO prediction
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
Early diagnosis of cancer may provide patients with more treatment options and hopefully prolong survival. The purpose of this multi-center study is to collect peripheral blood from newly diagnosed cancer patients and healthy donors to establish a blood cell RNA-based model for the differentiation of cancer patients and healthy donors. The area under the receiver operating characteristic (AUROC), sensitivity and specificity of the test in the early detection of multiple cancers will be measured.
Investigators
Zheng Wang, MD/PhD
Study chair, Clinical Professor
Wuhan Union Hospital, China
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Accuracy of TOO prediction
Time Frame: 1 year
Accuracy of the tissue of origin (TOO) prediction of a blood cell RNA-based cancer detection test
Sensitivity and specificity of cancer detection
Time Frame: 1 year
Sensitivity and specificity of the early detection of 30 types of cancers of a blood cell RNA-based cancer detection test