Flavopiridol in Treating Patients With Metastatic Malignant Melanoma
- Conditions
- Melanoma (Skin)
- Registration Number
- NCT00005971
- Lead Sponsor
- NCIC Clinical Trials Group
- Brief Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.
PURPOSE: Phase II trial to study the effectiveness of flavopiridol in treating patients who have metastatic malignant melanoma.
- Detailed Description
OBJECTIVES:
* Assess the efficacy of flavopiridol in patients with previously untreated metastatic malignant melanoma.
* Assess the toxicity of this treatment in these patients.
* Assess the time to progression, early progression rate, and response duration in these patients when treated with this regimen.
OUTLINE: This is a multicenter study.
Patients receive flavopiridol IV over 1 hour on days 1-3. Treatment continues every 21 days for a maximum of 6 courses in the absence of disease progression or unacceptable toxicity.
Patients are followed at 4 weeks, and then every 3 months until disease progression or death.
PROJECTED ACCRUAL: A total of 15-30 patients will be accrued for this study within 12-18 months.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 17
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (50)
York County Hospital
🇨🇦Newmarket, Ontario, Canada
Women's College Campus, Sunnybrook and Women's College Health Science Center
🇨🇦Toronto, Ontario, Canada
Credit Valley Hospital
🇨🇦Mississauga, Ontario, Canada
Mount Sinai Hospital - Toronto
🇨🇦Toronto, Ontario, Canada
Princess Margaret Hospital
🇨🇦Toronto, Ontario, Canada
Saint Joseph's Health Centre - Toronto
🇨🇦Toronto, Ontario, Canada
Lakeridge Health Oshawa
🇨🇦Oshawa, Ontario, Canada
Male Health Centre/CMX Research Inc.
🇨🇦Oakville, Ontario, Canada
North York General Hospital, Ontario
🇨🇦North York, Ontario, Canada
Toronto General Hospital
🇨🇦Toronto, Ontario, Canada
Penticton Regional Hospital
🇨🇦Penticton, British Columbia, Canada
G. Steinhoff Clinical Research
🇨🇦Victoria, British Columbia, Canada
St. Paul's Hospital - Vancouver
🇨🇦Vancouver, British Columbia, Canada
London Health Sciences Centre
🇨🇦London, Ontario, Canada
Newfoundland Cancer Treatment and Research Foundation
🇨🇦St. Johns, Newfoundland and Labrador, Canada
William Osler Health Centre
🇨🇦Brampton, Ontario, Canada
St. Michael's Hospital - Toronto
🇨🇦Toronto, Ontario, Canada
Cancer Care Ontario - Windsor Regional Cancer Centre
🇨🇦Windsor, Ontario, Canada
Maisonneuve-Rosemont Hospital
🇨🇦Montreal, Quebec, Canada
Scarborough Hospital - General Site
🇨🇦Scarborough, Ontario, Canada
Doctor Leon Richard Oncology Centre
🇨🇦Moncton, New Brunswick, Canada
Saint John Regional Hospital
🇨🇦Saint John, New Brunswick, Canada
Toronto East General Hospital
🇨🇦Toronto, Ontario, Canada
McGill University
🇨🇦Montreal, Quebec, Canada
Tom Baker Cancer Center - Calgary
🇨🇦Calgary, Alberta, Canada
Prostate Centre at Vancouver General Hospital
🇨🇦Vancouver, British Columbia, Canada
Lethbridge Cancer Clinic
🇨🇦Lethbridge, Alberta, Canada
Royal Victoria Hospital, Barrie
🇨🇦Barrie, Ontario, Canada
Northeastern Ontario Regional Cancer Centre, Sudbury
🇨🇦Sudbury, Ontario, Canada
Saskatoon Cancer Centre
🇨🇦Saskatoon, Saskatchewan, Canada
Humber River Regional Hospital
🇨🇦Weston, Ontario, Canada
Centre Hospitalier de l'Universite' de Montreal
🇨🇦Montreal, Quebec, Canada
Hotel Dieu de Montreal
🇨🇦Montreal, Quebec, Canada
Centre Hospitalier Universitaire de Quebec
🇨🇦Quebec City, Quebec, Canada
Nova Scotia Cancer Centre
🇨🇦Halifax, Nova Scotia, Canada
Trillium Health Centre
🇨🇦Mississauga, Ontario, Canada
Hamilton and Disrict Urology Association
🇨🇦Hamilton, Ontario, Canada
Peterborough Oncology Clinic
🇨🇦Peterborough, Ontario, Canada
Moncton Hospital
🇨🇦Moncton, New Brunswick, Canada
Northwestern Ontario Regional Cancer Centre, Thunder Bay
🇨🇦Thunder Bay, Ontario, Canada
Queen Elizabeth Hospital, PEI
🇨🇦Charlottetown, Prince Edward Island, Canada
Ottawa Regional Cancer Centre
🇨🇦Ottawa, Ontario, Canada
Hopital du Saint-Sacrament, Quebec
🇨🇦Quebec City, Quebec, Canada
Toronto Sunnybrook Regional Cancer Centre
🇨🇦Toronto, Ontario, Canada
Allan Blair Cancer Centre
🇨🇦Regina, Saskatchewan, Canada
Hotel Dieu Health Sciences Hospital - Niagara
🇨🇦St. Catharines, Ontario, Canada
CHUS-Hopital Fleurimont
🇨🇦Fleurimont, Quebec, Canada
Hopital Du Sacre-Coeur de Montreal
🇨🇦Montreal, Quebec, Canada
L'Hopital Laval
🇨🇦Ste-Foy, Quebec, Canada
Centre Hospitalier Regional de Lanaudiere
🇨🇦Joliette, Quebec, Canada