Timely identification of cognitive decline in multiple sclerosis (part of the Don*t be late! study)

Recruiting

• Conditions: MS; Multiple Sclerosis; 10003816; 10012303

• Registration Number: NL-OMON54277
• Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 8 July 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 750

Inclusion Criteria

- Confirmed MS diagnosis according to the McDonald 2017 criteria
- Age between 18 and 67
- No recent changes in disease modifying therapy (i.e., no changes in last 3
months)
- No current relapse or steroid treatment in the six weeks prior to the study
visit

Exclusion Criteria

- Patients with neurological (other than MS) and psychiatric disorders
- A current or history of drug or alcohol abuse
- Being unable to speak or read Dutch

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main outcome measures are: Sensitivity, specificity, negative and positive<br /><br>predictive value of Multiple Screener© compared to the gold standard (MACFIMS).</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary outcome measures include the test-retest reliability of the Multiple<br /><br>Screener© and the relationships between cognitive functioning (as measured with<br /><br>the Multiple Screener© and the MACFIMS test batter) and psychological,<br /><br>work-related and qualty of life measures. Additionally, the experiences with<br /><br>the discussion and assessment of cognitive functioning are secondary outcome<br /><br>measures. </p><br>