Complete Versus Lesion-only Primary PCI Pilot Study

Completed

• Conditions: ST elevation myocardial infarction (STEMI); Circulatory System; Myocardial infarction

• Registration Number: ISRCTN70913605
• Lead Sponsor: niversity Hospitals of Leicester NHS Trust (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2011-02-24
• Last Update Posted: 17 October 2016

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 1250

Inclusion Criteria

Registry:
1. Suspected or proven acute myocardial infarction
2. Significant ST elevation on electrocardiogram (ECG)
3. Less than 12 hours of symptom onset
4. Scheduled for primary percutaneous coronary intervention (PCI) for clinical reasons
5. Provision of verbal assent followed by written informed consent

RCT:
1. Suspected or proven acute myocardial infarction
2. Significant ST elevation on ECG
3. Less than 12 hours of symptom onset
4. Scheduled for Primary PCI for clinical reasons
5. Provision of verbal assent followed by written informed consent
6. Multivessel coronary disease detected at time of angiography

Exclusion Criteria

Registry:
There are no formal exclusion criteria for the CVLPRIT registry for patients that meet the inclusion criteria.

RCT:
1. Any contraindication to PPCI or multi-vessel PPCI
2. Less than 18 years age
3. Clear indication for or contraindication to multivessel PPCI, according to operator judgement and the reasons will be documented
4. Severe kidney impairment

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Cumulative major adverse cardiovascular events (MACE): all-cause mortality, recurrent MI, heart failure, need for revascularisation (PCI or CABG), measured up to 12 months