Does stress impair the inhibition of task-irrelevant emotional distracters during working memory?

• Conditions: acute (matige) stress; stress in healthy participants and posttraumatic stress disorder; 10009841

• Registration Number: NL-OMON31029
• Lead Sponsor: niversiteit Leiden

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 60

Inclusion Criteria

Healthy participants:
1) Participants are able to understand the given information
2) After being fully informed about the study and the risks informed consent should be signed
3) Participants are in excellent mental and physical condition
4) Age: > 18 yrs, < 55, and matched with PTSD patients
5) Body mass index: 19-26 kg/m²;
6) Sex: Male ;PTSD patients:
1) PTSD diagnosis as assessed with the SCID
2) Participants are able to understand the given information
3) After being fully informed about the study and the risks informed consent should be signed
4) Body mass index: 19-26 kg/m²;
5) Sex: Male

Exclusion Criteria

Exclusion criteria healthy participants
1) Use of medication (or remedies containing corticosteroids)
2) High blood pressure
3) Recent or past psychiatric problems
4) somatic illnesses

Exclusion criteria participants with PTSD
1) somatic illnesses
2) Repetitive psychotic episodes
3) The use of benzodiazepines more than the equivalent of 20 mg of oxazepam
4) The use of antipsychotic medication
5) Substance abuse and/or addiction (alcohol and drugs)
N.B. Stable use of SSRI*s is allowed.;For the MRI scanner: exclusion criteria: Metal implants, surgical clips, pacemakers, and left-handedness.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Behavioural measures: Reaction times on working memory task;<br /><br>Imaging: BOLD response during the task. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>BOLD response during rest (functional connectivity); Diffusion tensor imaging<br /><br>(structural connectivity).</p><br>