The Effect of Cosmetic Products Containing Assam Tea (Camellia Sinensis Var. Assamica) Extracts on Irritation, Moisturization, Skin Elasticity, Wrinkles, and Satisfaction in Volunteers.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- Skin hydration
研究概览
简要总结
Thailand has entered an aging society, prompting increased research on improving the elderly quality of life and preventing age-related diseases, with a particular focus on skin aging. Skin aging is linked to the degradation of dermal and epidermal tissue, leading to decreased collagen, elastin, and glycosaminoglycans, which causes reduced skin elasticity and wrinkles.
Assam tea is native to northern Thailand and is traditionally used in local products like fermented "Miang." Research shows that Assam tea contains high levels of polyphenols, particularly catechins, which have strong antioxidant properties that help combat conditions such as cancer, cardiovascular disease, and skin aging.
The study aims to study the effect of cosmetic products from Assam tea on irritation, moisturization, skin elasticity, wrinkles, and satisfaction in volunteers to enhance its value, particularly for the elderly. This effort is intended to boost the local economy, promote community-based tourism, and expand Assam tea products to national and international markets, ultimately improving livelihoods and addressing environmental concerns in northern Thailand.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 35 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Aged 35 years and older
- •Good physical and mental health
- •Willing and able to provide informed consent to participate and complete the entire duration of the study
排除标准
- •Women who are pregnant or breastfeeding
- •Presence of existing dermatological conditions
- •History of autoimmune disorders
- •Prior use of products related to wrinkle reduction or those containing active ingredients that stimulate collagen or elastin production, including topical and oral products used within the past three months (e.g., coenzyme Q10, marine extracts, pine bark extract, glutathione, and vitamin C)
- •Participation in any other volunteer study or program within the past three months
- •Use of the following medications within the past three months: contraceptives, phenytoin, hydantoin, levodopa, chloroquine, cancer chemotherapy drugs, or medications containing heavy metals
- •History of receiving dermatological or cosmetic procedures such as IPL (Intense Pulse Light) laser, phonophoresis, iontophoresis, laser treatments, Botox injections, fillers, or stem cell injections
- •Volunteers who exhibit sensitivity or irritation to the test products used in the study
结局指标
主要结局
Skin hydration
时间窗: 2 months
Measure skin hydration by using a Corneometer®
Transepidermal water loss (TEWL)
时间窗: 2 months
Measure TEWL by using a Tewameter®
Skin irritation
时间窗: 2 months
Evaluate redness and edema occurred after applying the tested products by closed patch test under occlusion with Finn chamber®
Values from Cutometer®
时间窗: 2 months
Such as R0, R1, R2, R3, R4, R5, R6, R7, R8, R9
Values from Skin-Visiometer®
时间窗: 2 months
Such as Volume, Surface, SEr, SEsc, SEsm, SEw
Sensory evaluation
时间窗: 2 months
Measure the parameters such as color, odor, viscosity, texture, etc using labeled affective magnitude scale
次要结局
未报告次要终点