Conjugated Linoleic Acid in Obese Women

Not Applicable

Completed

• Conditions: Obesity; Lipid Metabolism Disorders
• Interventions: Behavioral: Placebo; Dietary Supplement: CLA

• Registration Number: NCT02529046
• Lead Sponsor: Universidade Estadual de Londrina

Brief Summary

In this trial, the investigators analyzed the effects of eight weeks of CLA supplementation associated with aerobic exercise on body fat and lipid profile in obese women.

Detailed Description

The aim of this investigation was to analyze the effects of eight weeks of CLA supplementation associated with aerobic exercise on body fat and lipid profile in obese women. The investigators performed a randomized, double-blinded and placebo-controlled trial with 28 obese women who received 3.2 g/d of CLA or 4 g/d of olive oil (placebo group) while performing an 8-week protocol of aerobic exercise. Dietary intake (food record), body fat (DXA) and biochemical analysis (blood sample) were assessed before and after the intervention period.

Study Timeline

• Study Start: 2007-03
• Primary Completion: 2007-06
• Study Completion: 2007-07
• Status Verified: 2015-08
• Study First Submitted: 2015-08-04
• Study First Submitted QC: 2015-08-18
• Last Update Submitted: 2015-08-18
• Study First Posted: 2015-08-19
• Last Update Posted: 2015-08-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 28

Inclusion Criteria

• Had no signs or symptoms of disease
• No orthopedic injuries
• Must be inactive or moderately active (defined as performing any type of physical exercise less than twice a week)
• Must be non-smokers
• Must be free from the use of ergogenic aids
• Had no metabolic disorders or chronic degenerative diseases
• Not use drug therapy for body mass loss.

Exclusion Criteria

• Had frequency to training sessions below 85% of the total sessions

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Aerobic exercise	Placebo	Placebo group received 4 g/day of olive oil.
Aerobic exercise associated with CLA	CLA	CLA group received supplementation at a dose of 3.2 g/day (mixture of isomers of CLA isomers predominantly c9, t11 - 50% and c12, t10 - 80%).

Primary Outcome Measures

Name	Time	Method
Body fat	8 weeks	Dual-energy X-ray absorptiometry

Secondary Outcome Measures

Name	Time	Method
Total cholesterol	8 weeks	Blood analysis
Triglycerides	8 weeks	Blood analysis
High-density lipoprotein	8 weeks	Blood analysis
Low-density lipoprotein	8 weeks	Estimated by Friedewald formula
Trunk fat	8 weeks	Dual-energy X-ray absorptiometry
Arm fat	8 weeks	Dual-energy X-ray absorptiometry
Leg fat	8 weeks	Dual-energy X-ray absorptiometry

Trial Locations

Locations (1)

Universidade Estadual de Londrina; 🇧🇷 Londrina, Paraná, Brazil