How Effective Is Iron drip in Helping Cancer Surgery Patients Recover?

Not yet recruiting

Conditions: Medical and Surgical,

Registration Number: CTRI/2025/05/087381

Lead Sponsor: Tata Memorial Centre

Brief Summary: Anemia, a condition where the blood lacks enough healthy red blood cells to carry oxygen, is common in cancer patients scheduled for major abdominal surgeries. It affects 30–60% of these patients and can lead to complications such as increased need for blood transfusions, delayed recovery, and longer hospital stays. Traditional treatments like oral iron supplements often fail to address this anemia effectively because cancer and related conditions interfere with how the body processes and uses iron.

This study aims to explore the use of intravenous (IV) iron therapy to treat anemia before surgery. Unlike oral supplements, IV iron bypasses the barriers caused by inflammation and allows for faster correction of anemia. By improving hemoglobin before surgery, we hope to reduce the need for blood transfusions during or after the operation, lower the risk of complications, and speed up recovery.

Over one year, we will monitor cancer patients undergoing elective abdominal surgeries at our hospital. We will examine how effective IV iron therapy is in improving hemoglobin levels, reducing blood transfusions, and ensuring better overall outcomes. This research is especially important in countries like India, where anemia is highly prevalent, and effective management could significantly improve peri-operative outcomes.

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 350

Inclusion Criteria

Haemoglobin less than 12g/dl in females and less than 13g/dl in males 2.All elective major abdominal oncosurgeries (Upper and lower gastrointestinal surgeries, Hepatico-pancreatico-biliary surgeries, Urological and Gynaecological surgeries) 3.Patients over the age of 18 years.

Exclusion Criteria

1.Emergency surgery 2.H/o allergy to parenteral iron preparations 3.Patients with recurrent or second primary cancer 4.Palliative surgery 5.Patients with chronic liver disease, chronic kidney disease, iron storage disorder, haematological malignancy and hemoglobinopathies.

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Increase in mean Hemoglobin value after preoperative intravenous therapy to treat anaemia	Hb at first visit, Preoperative Hb, Postoperative Hb

Secondary Outcome Measures

Name	Time	Method
1.To study the effect of intravenous haematinics on the number of PRBC transfusions during and within 72 hours after surgery in comparison with patients without iron therapy	2.Incidence of anemia in patients undergoing major abdominal oncosurgeries

Trial Locations

Locations (1): Advanced Centre for Treatment, Research and Education in Cancer(ACTREC)
🇮🇳
Raigarh, MAHARASHTRA, India
Advanced Centre for Treatment, Research and Education in Cancer(ACTREC)
🇮🇳Raigarh, MAHARASHTRA, India
Dr Reshma Ambulkar
Principal investigator
9821790448
rambulkar@hotmail.com