IMPROVE-study
- Conditions
- Cervical Intraepithelial Neoplasia (CIN), Cervical cancer
- Registration Number
- NL-OMON28209
- Lead Sponsor
- VU University Medical Center, Department of PathologyErasmus Medical Center, Department of PathologyRadboud University Medical Center, Department of GynaecologyNational Institute for Public Health and the Environment (RIVM)
- Brief Summary
Gök et al. BMJ 2010<br> Gök et al. Int J Cancer 2011<br> Verhoef et al. Lancet Oncol 2014<br> Bosgraaf et al. Int J Cancer 2014<br>
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 12000
Inclusion Criteria
1. Women invited for the national screening program in 2015 (ages 30-60 years)
2. Women should reside in the regions covered by district health authorities of Noord-Holland, Flevoland, Utrecht, Zuid-Holland, Zeeland, Gelderland en Overijssel (in the Netherlands)
Exclusion Criteria
1. Not in the population based screening program, i.e. ages under 30 years or over 60 years
2. Cervical smear in the past 12 months or under follow-up/treatment by gynaecologist
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The number of CIN2+ and CIN3+ lesions in both study arms
- Secondary Outcome Measures
Name Time Method Comparison of the cost-effectiveness between both study arms