The Frequency and Risk Factors of Delayed Graft Function

Completed

• Conditions: Delayed Graft Function; Kidney Transplant; Complications
• Interventions: Procedure: living kidney transplantation

• Registration Number: NCT03555513
• Lead Sponsor: nooshin dalili

Brief Summary

Delayed graft function (DGF) is an important phenomenon after kidney transplantation with direct and indirect implication on graft survival. Although its incidence and risk factors have been studied after cadaveric kidney transplantation cases, only few data is available regarding transplants from living donors. The present study was performed to investigate the frequency and risk factors of DGF among living-unrelated kidney transplant recipients among three transplant centers in part of Middle East.

Detailed Description

In this multi-center retrospective study, data from 480 transplanted patients had been collected from existing local hospital registries in three countries (Iran, Kingdom of Saudi Arabia (KSA), and Kuwait) with 3 years post transplantation follow-up. Data for this study was collected based on routine clinical practice of medical practitioners across the participating countries. A case report data collecting form was designed for gathering the data including the recipient and donor's characteristics prior to transplantation, and after transplantation up to three years post transplantation. Using binary logistic regression analysis, the potential risk factors for occurrence of DGF in living donor transplantations were tested. Graft and patient survival at 1, 2 and 3 years depending on follow-up time was evaluated.

Study Timeline

• Study Start: 2016-01-01
• Primary Completion: 2017-01-01
• Study Completion: 2017-03-01
• Status Verified: 2018-06
• Study First Submitted: 2018-06-01
• Study First Submitted QC: 2018-06-01
• Last Update Submitted: 2018-06-01
• Study First Posted: 2018-06-13
• Last Update Posted: 2018-06-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 500

Inclusion Criteria

Living donor kidney recipients with complete prior transplantation data and 3 years post transplantation follow up, including those who died during the observation period

Exclusion Criteria

kidney recipients younger than 18 years

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
living kidney transplanted patients	living kidney transplantation	Any patients over 18 who received kidney transplantation from living donor

Primary Outcome Measures

Name	Time	Method
incidence of delayed graft function	3 years

Secondary Outcome Measures

Name	Time	Method
risk factors of DGF	three years