MIND-TIA: Markers in the Diagnosis of TIA

Completed

Conditions: mini-stroke
Transient Ischemick Attack (TIA)
10007963

Registration Number: NL-OMON38622

Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 350

Inclusion Criteria

* Being adult (18 years and older)
* Presenting to the GP with a new episode of symptoms suspected of TIA and the GP considering further investigations to confirm or exclude TIA at the TIA outpatient clinic.
* A blood sample can be collected within 72 hours after onset of symptoms.

Exclusion Criteria

* The patient still has active symptoms or signs suspected of an ongoing ischemic stroke and immediate referral to the neurologist seems indicated.
* Valid history taking is impossible because of severe cognitive impairment or insufficient knowledge of the Dutch language.
* Patient with a life expectancy of < 6 months.
* Patient is not willing or able to give written informed consent

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameter is the level of a set of biomarkers in a venous blood<br /><br>sample taken within 72 hours after onset of symptoms. Main study endpoint is<br /><br>the definite diagnosis of TIA (reference standard), which will be established<br /><br>by an expert panel consisting of three neurologists using all available<br /><br>diagnostic information including imaging of the brain and 6 months of<br /><br>follow-up.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary parameters:<br /><br>Possible factors influencing doctors and patients delay<br /><br><br /><br>Secondary endpoints:<br /><br>- Endpoints during 6months of follow-up: (ischemic) cerebrovascular events,<br /><br>(ischemic) cardiovascular events, and mortality.<br /><br>- Time delay (f.e. time to first of action of the patient, time to GP<br /><br>consultation)</p><br>