Electroanatomic Origin of Premature Atrial Beats in Patients With Paroxysmal Atrial Fibrillation Induced by Intra-thoracic Pressure Swings Simulating Obstructive Sleep Apnea
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 2
- 试验地点
- 2
- 主要终点
- Electroanatomical origin of premature atrial beats
研究概览
简要总结
There is accumulating evidence for obstructive sleep apnea (OSA) as an independent risk factor for paroxysmal atrial fibrillation and for high recurrence rates of atrial fibrillation after ablation therapy. We have previously shown that simulated OSA triggers premature atrial beats (PABs) by acute changes in intra-thoracic pressure. Most episodes of atrial fibrillation are initiated by PABs. However, the origin of PABs induced by intra-thoracic pressure swings is unknown. This study investigates the origin of premature atrial beats induced by intra-thoracic pressure changes that simulate obstructive sleep apnea in patients with atrial fibrillation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •History of ECG-documented paroxysmal atrial fibrillation within the last 12 months and currently in sinus rhythm
- •Scheduled for circumferential pulmonary venous isolation treatment
- •18 to 75 years of age
- •Signed informed consent
排除标准
- •Treated with class III anti-arrhythmic agents (at the moment of pulmonary venous isolation)
- •Treated for obstructive sleep apnea
- •Previous catheter ablation in the pulmonary veins or left atrium
- •Severe structural heart disease
- •Mental or physical disability precluding informed consent or compliance with the protocol
- •Enrolled in another study that would confound the results of this trial
结局指标
主要结局
Electroanatomical origin of premature atrial beats
时间窗: Participants will be followed for the duration of pulmonary vein isolation, an expected average of 3 hours
(Loop-)Catheter-based origin detection in patients with apnea-hypopnea index \> 5/h in home sleep study and documented premature atrial beats during three time points: baseline (normal breathing), inspiration through a threshold load device, and the Mueller Manoeuvre (MM). Origins will be quantitatively marked at a left atrial map.
次要结局
- Catheter-based pressure in the left atrium and pulmonary veins during intra-thoracic pressure changes(Participants will be followed for the duration of pulmonary vein isolation, an expected average of 3 hours)
研究者
Malcolm Kohler
Malcolm Kohler, Prof MD
University of Zurich