Vitamin d Level and it's Association With Disease Activity in Egyptian Rheumatoid Arthritis Patients
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 130
- 主要终点
- prevalence of vitamin D dificency in Rheumatoid arthritis
研究概览
简要总结
Vitamin D level and its association with disease activity in Egyptian Rheumatoid arthritis (RA) patients
详细描述
Rheumatoid arthritis (RA) is a chronic inflammatory disease that affects about 1% of the human population. Its incidence increases between 25 and 55 years and is the most common type of chronic inflammatory arthritis . It affects joints bilaterally with synovial hyperplasia, cartilage erosion, bone destruction, and progressive loss of function . also characterized by systemic features and joint involvement. It can lead to significant morbidity and mortality so early diagnosis and proper treatment are crucial in decreasing the burden of this disease . According to the World Health Organization mortality database of 31 countries, RA accounts for almost 18% of all deaths caused by different types of arthritis and other musculoskeletal diseases, but the exact cause of RA remains unknown
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Both males and females in the age group of 1875 years having RA according to the American College of Rheumatology European League Against Rheumatism 2010 criteria (Meena et al., 2018). Will enrolled in this study
排除标准
- •Patients with malnutrition, hepatic and renal dysfunction, hyperparathyroidism, hyperthyroidism, diabetes mellitus, and patients on Vitamin D supplementation in the past 6 months or on medications that can affect bone and Vitamin D metabolism (anticonvulsants, diuretics, and thyroxin) were excluded from this study.
- •Patients with overlap syndrome
- •known allergy to DMARDs, 1,25 dihydroxy vitamin D3 or calcium supplements
研究组 & 干预措施
65 rheumatoid arthritis patient
Vitamin d effect on rheumatoid arthritis activity on 65 rheumatoid arthritis patients and 65 healthy population
干预措施: Vit D (Drug)
65 healthy population
Vitamin d effect on rheumatoid arthritis activity on 65 rheumatoid arthritis patients and 65 healthy population
干预措施: Vit D (Drug)
结局指标
主要结局
prevalence of vitamin D dificency in Rheumatoid arthritis
时间窗: 3 years
prevalence of vitamin D dificency in Rheumatoid arthritis Egyption patients compared by healthy patients
次要结局
未报告次要终点
研究者
Mariam Samir Farg
Mariam farag
Assiut University