Exploratory study into age-related immunological differences related to immunogenicity in influenza vaccination and herpes zoster vaccinatio

Completed

Conditions: herpes zoster
Influenza
10047438

Registration Number: NL-OMON50860

Lead Sponsor: Radboud Universitair Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 147

Inclusion Criteria

• Healthy
• Age between 18-35 years old OR age >=65 years old
• Written informed consent

Exclusion Criteria

• Known allergy to (components of) the influenza or herpes zoster vaccine
• Immunocompromised subjects
• Previous herpes zoster vaccination in the last year
• Receipt of any vaccination 4 weeks prior to the start of the study or plans
to receive any other vaccination until 2 months after inclusion
• Chronic use of systemic drugs other than oral contraceptives
• Use of NSAIDS less than 4 weeks prior to the start of the study
• Acute or active illness within two weeks prior to the start of the study
• Pregnant, breastfeeding or planning to become pregnant during the study
period

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Functional assessment of vaccine response (including but not limited to<br /><br>antibody responses, cellular mediated immune responses, cross-omics, cytokine<br /><br>production)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Safety data (solicited AEs, unsolicited AEs, SAEs, MAAEs, AESIs, AEs leading to<br /><br>withdrawal from the study and unintentional exposure during<br /><br>pregnancy)</p><br>