Prevalence of Cardiac Amyloidosis in Heart Failure Patients With Preserved Left Ventricular Ejection Fraction in Tunisia
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Cardiac Amyloidosis
- Sponsor
- University Tunis El Manar
- Enrollment
- 87
- Locations
- 1
- Primary Endpoint
- Prevalence of cardiac amyloidosis among HFpEF old Tunisian Patients
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
Cardiac amyloidosis (CA) has recently been reported as a common cause of heart failure with preserved left ventricular ejection fraction (HFpEF), with a prevalence of 6% in elderly HFpEF patients. However, the diagnosis of CA is still challenging and requires multiple costly investigations.
Regardless of the type of CA, TTR or AL, early diagnosis significantly improves prognosis.
In this study, the investigators aimed to determine the prevalence of CA in Tunisian HFpEF patients and to identify clinical and ultrasound criteria predictive of CA.
Investigators
Lilia Zakhama
Professor
University Tunis El Manar
Eligibility Criteria
Inclusion Criteria
- •HFpEF during the previous year
- •IVS thickness of 12mm or greater
Exclusion Criteria
- •age under 60 years
- •Acute coronary syndrome complicated by HFpEF
- •Congenital heart disease
Outcomes
Primary Outcomes
Prevalence of cardiac amyloidosis among HFpEF old Tunisian Patients
Time Frame: one year
Prevalence of cardiac amyloidosis in a Tunisian cohort of HFpEF patients aged 60 years or older with interventricular septal thickness equal to or greater than 12 mm
Secondary Outcomes
- Frequency of different types of cardiac amyloidosis(one year)
- Identify imaging criteria predictive of cardiac amyloidosis on CMR and echocardiography(one year)