Valeur Pronostique Dans Une Population d'Amylose Cardiaque Des paramètres échocardiographiques basée Sur Une Approche d'Apprentissage Automatique
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Transthyretin Cardiac Amyloidosis
- Sponsor
- Pr. Nicolas GIRERD
- Enrollment
- 1000
- Locations
- 4
- Primary Endpoint
- Rate of hospitalisation for acute heart failure
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
Transthyretin cardiac amyloidosis is an increasingly recognized cause of heart failure with preserved ejection fraction. Its diagnosis is currently based on a non-invasive method including biology and imaging. Still currently incurable, the evolution of this pathology is burdened by numerous comorbidities, including iterative hospitalizations for heart failure leading to death. The Machine Learning approach has already shown its efficiency in terms of diagnosis but its prognostic approach has not yet been studied.
Investigators
Pr. Nicolas GIRERD
Professor
Central Hospital, Nancy, France
Eligibility Criteria
Inclusion Criteria
- •Patients with suspicion of transthyretin cardiac amyloidosis
- •Age ≥18 years
Exclusion Criteria
- •Lack of data to confirm or overturn the transthyretin amyloidosis diagnostic
- •Echocardiographic data not allowing deep analysis (technical default, bad echogenicity of the patient)
- •Final diagnostic of AL or AA amyloidosis
Outcomes
Primary Outcomes
Rate of hospitalisation for acute heart failure
Time Frame: Minimum 1-year follow-up and until last news available
composite endpoint: rate of death from all causes and hospitalisation for acute heart failure following inclusion (with outcome 1)
Rate of death from all causes
Time Frame: Minimum 1-year follow-up and until last news available
composite endpoint: rate of death from all causes and hospitalisation for acute heart failure following inclusion (with outcome 2
Secondary Outcomes
- Implantation of pacemaker/defibrillator during study(Minimum 1-year follow-up and until last news available)
- Rate of death from all causes and hospitalisation for acute heart failure(Minimum 1-year follow-up and until last news available)
- Rate of hospitalisation for acute heart failure(Minimum 1-year follow-up and until last news available)
- Rate of death from all causes(Minimum 1-year follow-up and until last news available)
- Rate of hospitalisation for acute heart failure (including repeated hospitalisation)(Minimum 1-year follow-up and until last news available)