Valeur Pronostique Dans Une Population d'Amylose Cardiaque Des paramètres échocardiographiques basée Sur Une Approche d'Apprentissage Automatique
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 1,000
- 试验地点
- 4
- 主要终点
- Rate of hospitalisation for acute heart failure
研究概览
简要总结
Transthyretin cardiac amyloidosis is an increasingly recognized cause of heart failure with preserved ejection fraction. Its diagnosis is currently based on a non-invasive method including biology and imaging. Still currently incurable, the evolution of this pathology is burdened by numerous comorbidities, including iterative hospitalizations for heart failure leading to death. The Machine Learning approach has already shown its efficiency in terms of diagnosis but its prognostic approach has not yet been studied.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with suspicion of transthyretin cardiac amyloidosis
- •Age ≥18 years
排除标准
- •Lack of data to confirm or overturn the transthyretin amyloidosis diagnostic
- •Echocardiographic data not allowing deep analysis (technical default, bad echogenicity of the patient)
- •Final diagnostic of AL or AA amyloidosis
结局指标
主要结局
Rate of hospitalisation for acute heart failure
时间窗: Minimum 1-year follow-up and until last news available
composite endpoint: rate of death from all causes and hospitalisation for acute heart failure following inclusion (with outcome 1)
Rate of death from all causes
时间窗: Minimum 1-year follow-up and until last news available
composite endpoint: rate of death from all causes and hospitalisation for acute heart failure following inclusion (with outcome 2
次要结局
- Implantation of pacemaker/defibrillator during study(Minimum 1-year follow-up and until last news available)
- Rate of death from all causes and hospitalisation for acute heart failure(Minimum 1-year follow-up and until last news available)
- Rate of hospitalisation for acute heart failure(Minimum 1-year follow-up and until last news available)
- Rate of death from all causes(Minimum 1-year follow-up and until last news available)
- Rate of hospitalisation for acute heart failure (including repeated hospitalisation)(Minimum 1-year follow-up and until last news available)
研究者
Pr. Nicolas GIRERD
Professor
Central Hospital, Nancy, France