Comparison of De-Epithelialized Gingival Graft With or Without Platelet Rich Fibrin in Multiple Gingival Recessions

Not Applicable

Completed

• Conditions: Gingival Recession, Generalized
• Interventions: Procedure: DGG+PRF; Procedure: DGG

• Registration Number: NCT06509867
• Lead Sponsor: Kutahya Health Sciences University

Brief Summary

The aim of this study is to compare the clinical efficacy and patient reported outcome measures of de-epithelialized gingival graft (DGG) with or without platelet rich fibrin on treatment of multiple adjacent gingival recessions with coronally advanced flap (CAF) technique.

Detailed Description

Fifteen patients with split-mouth multiple gingival recessions affecting at least 3 adjacent teeth will be treated with either DGG or DGG+PRF. Recession depth(RD) and width(RW), probing depth(PD), clinical attachment level(CAL), keratinized tissue width (KTW), gingival thickness(GT), and percentage of root coverage (RC%) will be evaluated at 1, 3 and 6 months postoperatively. For patient reported outcome measurements, oral health impact factor-14 (OHIP-14) scores, postoperative pain, bleeding, discomfort and painkiller consumption will be recorded.

A total of 15 patients will surgically treated with coronally advanced flap (CAF) associated with de-epithelialized gingival graft. Groups were defined as DGG and DGG+PRF:

DGG Group (n=15): de-epithelialized subepithelial connective tissue grafts + coronally advanced flap DGG+PRF Group (n=15): de-epithelialized subepithelial connective tissue grafts+ L-Platelet Rich Fibrin + Coronally advanced flap

Study Timeline

• Study Start: 2019-05-30
• Primary Completion: 2020-10-30
• Study Completion: 2021-04-30
• Study First Submitted: 2024-07-15
• Study First Submitted QC: 2024-07-15
• Study First Posted: 2024-07-19
• Status Verified: 2024-08
• Last Update Submitted: 2024-08-05
• Last Update Posted: 2024-08-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Platelet rich fibrin	DGG+PRF	de-epithelialized subepithelial gingival grafts+ L-Platelet Rich Fibrin + Coronally advanced flap
de-epithelialized gingival grafts	DGG	de-epithelialized gingival grafts + coronally advanced flap

Primary Outcome Measures

Name	Time	Method
percentage of root coverage	at 6th month	Percentage of Root Coverage (RC%) were performed with the following formulas. RC%: \[(Preoperative RD-Postoperative RD)/ Preoperative RD\] x 100.

Trial Locations

Locations (1)

Gazi University Faculty of Dentistry; 🇹🇷 Ankara, Turkey