microbiome of asthmatic smokers
- Conditions
- Diseases of th respiratory system
- Registration Number
- KCT0002252
- Lead Sponsor
- Chung-Ang Univerisity Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 40
Asthma (Any of the following criteria)?
-Bronchodilator response (+): FEV1(Forced Expiratory Volume in the first second) increase >12% and 200 mL
-FEV1 (forced expiratory volume 1) variation (>12% and 200 ml) with or without treatment >12% and 200 mL
-Airway hyperresponsiveness (+) to methacholine or mannitol provocation
1. Severe medical condition (life expectancy <3 years) and current cancer 2. Severe psychiatric diseases 3. Other active airway or pulmonary (tuberculosis etc) 4. Recent exacerbation (within 3 months) 5. =40 Pack Year smoker in order to exclude COPD 6. Usage of drugs below 1 month ?:Antibiotics, antifungal agents, antiviral repellents Steroids: oral, intravenous, intramuscular that can activate inhibit the immune system: cytokines, methotrexate, anticancer drug) 7. Food: probiotics, prebiotics>
Study & Design
- Study Type
- Observational Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Bacterial community analysis of airway specimens by 16S rRNA metagenomic sequencing
- Secondary Outcome Measures
Name Time Method Analysis of the immune system, microbiome analyzed subjects