Acute Effects of Smoking on Airway Dendritic Cells

Not Applicable

Completed

• Conditions: Tobacco Use Disorder
• Interventions: Behavioral: Smoking

• Registration Number: NCT00740896
• Lead Sponsor: University of Rostock

Brief Summary

Airway dendritic cells control pulmonary immune responses to inhaled particles. It is the aim of the present study to investigate the acute effects of smoking on the number and surface molecule expression of human airway dendritic cells.

Detailed Description

Not available

Study Timeline

• Study Start: 2008-06
• Study First Submitted: 2008-08-22
• Study First Submitted QC: 2008-08-22
• Study First Posted: 2008-08-25
• Primary Completion: 2008-11
• Study Completion: 2008-12
• Status Verified: 2009-04
• Last Update Submitted: 2009-04-07
• Last Update Posted: 2009-04-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 16

Inclusion Criteria

• Active smoking (at least 10 cigarettes per day)
• Age > 18 years

Exclusion Criteria

• Any chronic diseases
• Any regular medication
• Any signs or symptoms of an acute infection

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
1	Smoking	Participants smoke 8 cigarettes in 4 hours.
2	Smoking	Participants are not allowed to smoke for 4 hours.

Primary Outcome Measures

Name	Time	Method
Total number of dendritic cells in bronchoalveolar lavage fluid	June - September 2008

Secondary Outcome Measures

Name	Time	Method
Surface molecule expression on dendritic cells in bronchoalveolar lavage fluid	June - September 2008

Trial Locations

Locations (1)

University of Rostock; 🇩🇪 Rostock, Germany