Pathophysiologic Changes in the Respiratory System After Fire Smoke Inhalation

Not Applicable

Completed

• Conditions: Bronchial Asthma
• Interventions: Other: Fiberoptic bronchoscopy

• Registration Number: NCT01240707
• Lead Sponsor: Oslo University Hospital

Brief Summary

Fire smoke inhalation may contribute to intrabronchial inflammation, airway obstruction and impaired gas exchange. In this study the investigators will examine if the scope of inhalation injury can be assessed soon after hospital admission based on clinical markers, biochemical markers, Peak Expiratory Flow (PEF), spirometry and bronchoscopy. At 6 months a lung function test and metacholine test will be performed to examine whether patients have developed increased bronchial hyperreactivity (asthma) or not after the initial fire smoke exposure.

Detailed Description

Fire smoke inhalation may contribute to intrabronchial inflammation, airway obstruction and impaired gas exchange. The scope of injury in fire smoke victims ranges from cough and minor airway irritation to severe respiratory failure and long term mechanical ventilation in the Intensive Care Unit. Some patients with high HbCO-levels are also treated with hyperbaric oxygen therapy.

In this study the investigators will examine if the scope of inhalation injury can be assessed soon after admission based on clinical markers, biochemical markers, Peak Expiratory Flow (PEF), spirometry and bronchoscopy. The clinical effect of fiberoptic bronchoscopy after severe smoke inhalation will also be examined. At 6 months a lung function test and metacholine test will be performed to examine whether they have developed asthma/increased bronchial hyperreactivity or not after the initial fire smoke exposure. Lab staff (flowcytometer and cytokine analysis) are unaware of patient identity and whether the patient is a smoke-exposed patient or a healthy volunteer in the control group of non-exposed persons.

Study Timeline

• Study Start: 2010-11
• Study First Submitted: 2010-11-10
• Study First Submitted QC: 2010-11-12
• Study First Posted: 2010-11-15
• Primary Completion: 2016-05
• Study Completion: 2016-05
• Status Verified: 2016-09
• Last Update Submitted: 2016-09-26
• Last Update Posted: 2016-09-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• fire smoke exposed patient
• > 18 years of age
• admitted to hospital

Exclusion Criteria

• < 18 years of ager
• trauma patient

Control group (healthy volunteers/hospital staff):

• > 18 years of age
• non-smoker
• no exposure to fire smoke

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
LF tests, Fiberoptic bronchoscopy	Fiberoptic bronchoscopy	Spirometry, Peak Expiratory Flow (PEF). Bronchoscopic assessment of soot in central airways.

Primary Outcome Measures

Name	Time	Method
Positive metacholine test (bronchial hyperreactivity).	6 months	At 6 months a lung function test and metacholine test will be performed to examine whether patients have developed asthma/increased bronchial hyperreactivity after the initial fire smoke exposure.

Trial Locations

Locations (1)

Oslo University Hospital - Ulleval; 🇳🇴 Oslo, Norway