Influence of a Prematuration Culture With a Phosphodiesterase-3 Inhibitor (PDE3-I) on Embryonic Aneuploidy Rate and Developmental Potential

Phase 1

Terminated

• Conditions: Infertility
• Interventions: Procedure: prematuration culture

• Registration Number: NCT00823420
• Lead Sponsor: Universitair Ziekenhuis Brussel

Brief Summary

A single centre randomised controlled trial investigating the influence of a novel prematuration system (PMS) using a phosphodiesterase-3 inhibitor for in-vitro maturation of oocytes

Detailed Description

Not available

Study Timeline

• Status Verified: 2009-01
• Study First Submitted: 2009-01-13
• Study First Submitted QC: 2009-01-13
• Study First Posted: 2009-01-15
• Study Start: 2009-05
• Primary Completion: 2012-10
• Study Completion: 2012-10
• Last Update Submitted: 2014-12-04
• Last Update Posted: 2014-12-05

Recruitment & Eligibility

• Status: TERMINATED
• Sex: Female
• Target Recruitment: 213

Inclusion Criteria

• healthy volunteers, either with PCOS/PCOS-like ovaries, or with normal ovaries, who undergo oocyte donation for research
• AFC at least 10
• AMH: > 5 μg/L
• Female age < 36 years

Exclusion Criteria

• major uterine or ovarian abnormalities

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
in-vitro maturation of oocytes	prematuration culture	-

Primary Outcome Measures

Name	Time	Method
Incidence of aneuploidy rate by fluorescence in situ hybridisation (FISH) technique in 6 to 8 cell embryos from prolonged (PMC) IVM compared to conventional IVM on sibling oocytes.	3 days after egg retrieval

Secondary Outcome Measures

Name	Time	Method
Implantation potential of embryos from conventional IVM performed on Type II COC. Efficiency of both maturation systems in obtaining blastocysts. Endometrium quality in IVM cycles.	7 days after egg retrieval

Trial Locations

Locations (1)

Centre for Reproductive Medicine; 🇧🇪 Brussels, Belgium