Influence of a Prematuration Culture With a Phosphodiesterase-3 Inhibitor (PDE3-I) on Embryonic Aneuploidy Rate and Developmental Potential
Phase 1
Terminated
- Conditions
- Infertility
- Interventions
- Procedure: prematuration culture
- Registration Number
- NCT00823420
- Lead Sponsor
- Universitair Ziekenhuis Brussel
- Brief Summary
A single centre randomised controlled trial investigating the influence of a novel prematuration system (PMS) using a phosphodiesterase-3 inhibitor for in-vitro maturation of oocytes
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- Female
- Target Recruitment
- 213
Inclusion Criteria
- healthy volunteers, either with PCOS/PCOS-like ovaries, or with normal ovaries, who undergo oocyte donation for research
- AFC at least 10
- AMH: > 5 μg/L
- Female age < 36 years
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Exclusion Criteria
- major uterine or ovarian abnormalities
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Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description in-vitro maturation of oocytes prematuration culture -
- Primary Outcome Measures
Name Time Method Incidence of aneuploidy rate by fluorescence in situ hybridisation (FISH) technique in 6 to 8 cell embryos from prolonged (PMC) IVM compared to conventional IVM on sibling oocytes. 3 days after egg retrieval
- Secondary Outcome Measures
Name Time Method Implantation potential of embryos from conventional IVM performed on Type II COC. Efficiency of both maturation systems in obtaining blastocysts. Endometrium quality in IVM cycles. 7 days after egg retrieval
Trial Locations
- Locations (1)
Centre for Reproductive Medicine
🇧🇪Brussels, Belgium