A study of the connectivity measures of a resting-state brain network in patients with Epilepsy.

Recruiting

• Conditions: Epilepsy; Neurological - Epilepsy

• Registration Number: ACTRN12618000193279
• Lead Sponsor: The Royal Melbourne Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-02-07
• Last Update Posted: 28 January 2019

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Diagnosis of Idiopathic Generalised Epilepsy (IGE) or Temporal Lobe Epilepsy (TLE), right-handedness, able to provide written informed consent in English.

Exclusion Criteria

Any contraindication to a 7-Tesla MRI scan (a detailed safety questionnaire will be used).

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Glutamate concentrations as measured by MRS of the Posterior Cingulate Cortex.[Single scan, concomitant with fMRI. ];GABA concentration as measured by MRS of the Posterior Cingulate Cortex[Single scan, concomitant with fMRI. ];Fisher-transformed correlation coefficient values between regions of the Default Mode Network and between the Posterior Cingulate Cortex to all brain regions via resting state fMRI. [Single scan, concomitant with MRS.]

Secondary Outcome Measures

Name	Time	Method
Duration of epilepsy - will be defined from first seizure, self-reported by study participants. [At enrolment. ];Seizure frequency. It will be self-reported by the study participants and scored from 0 to 4:<br>0 = seizure-free (no seizures during the previous 3 months);<br>1 = =1 seizures during the last 3 months, but not within the past month;<br>2 = =1 seizures per month;<br>3 = =1 seizures per week;<br>4 = =1 seizures per day.<br>The past seizure frequency will be assessed during a period of only 3 months to reduce recall bias. [At enrolment.];EEG characteristics - distribution, type and frequency of epileptiform discharges.[EEG results will be checked immediately following enrolment. ];Number of antiepileptic medications being used by the participant as self-reported by the participant (presently used at the time of enrolment).[At enrolment. ]