Characterisation of neurotransmitter network dysfunction in MRI-negative localisation-related epilepsy

Completed

• Conditions: Epilepsy; falling sickness; 10039911

• Registration Number: NL-OMON40961
• Lead Sponsor: Medisch Universitair Ziekenhuis Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2016-11-15
• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 24

Inclusion Criteria

General:
Subjects must be older than 18 years and able to give informed consent. ;Epilepsy patients:
- Diagnosed with cryptogenic localization-related epilepsy with an epileptic focus in the frontal or temporal lobe (using EEG)
- Seizure frequency below 13/year.
- No changes in anti-epileptic drugs (medication or dose) in the last 6 months.

Exclusion Criteria

General:
- MRI visible lesions, as seen on the clinical 3T scans
- All absolute or relative contraindications for MR scanning.
- A medical history with cerebral diseases (other than epilepsy), vascular problems, diabetes mellitus, hypertension and/or cerebral surgery.

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary study parameters are the neurotransmitter network properties of<br /><br>MRI-negative localization-related epilepsy patients compared to those of<br /><br>healthy subjects.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary study parameters are functional and structural network properties and<br /><br>the relation between these and the neurotransmitter network properties of<br /><br>MRI-negative localisation-related epilepsy patients. </p><br>