Onderzoek naar afwijkingen in het brein netwerk bij epilepsie
- Conditions
- epilepsy
- Registration Number
- NL-OMON25197
- Lead Sponsor
- Academic hospital Maastricht (azM)
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
Subjects must be older than 18 years and able to give informed consent. Furthermore, for the epilepsy subjects the following criteria apply:
- Diagnosed with cryptogenic localization-related epilepsy with an epileptic focus in the frontal or temporal lobe (using EEG)
Exclusion Criteria
- MRI visible lesions, as seen on the clinical 3T scans
- All absolute or relative contraindications for MR scanning: e.g. metallic prostheses, pacemakers, neurostimulators, metal clips on blood vessels, metal parts in the eye, an intrauterine device, metal braces and other metal objects in the body; pregnancy and claustrophobia; tattoos.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The network properties of the NAA/Cr and GABA/glu networks derived from MRSI. These network metrics include average node degree, characteristic path length and cluster coefficient.
- Secondary Outcome Measures
Name Time Method The relationship between the MRSI, fMRI and dMRI derived network properties.