A Randomized Study on the Value of an Endometrial Scratch Prior to a Frozen Embryo Transfer Cycle in the Treatment of Recurrent Implantation Failure
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 发起方
- 主要终点
- clinical pregnancy rate
研究概览
简要总结
Patients with a history of recurrent implantation failure who are planning a frozen embryo transfer (FET) are enrolled into the program. Patients are randomized to an endometrial biopsy prior to starting estrogen to prepare for the transfer of warmed vitrified embryos or to routine care.
详细描述
Patients who failed to achieve a clinical pregnancy after embryo transfer of at least three high quality embryos in at least two IVF or FET cycles and for whom their last failed cycle was a frozen embryo transfer are offered the opportunity to enroll in this study. All patients will follow our routine FET protocol.
On a randomized basis, selected patients will undergo an endometrial biopsy using a Pipelle disposable device in the week prior to starting estrogen to prepare her endometrium.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 49 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •At least two prior consecutive failed IVF or FET cycles with transfer of at least 3 high quality embryos and with last cycle a FET cycle
排除标准
- •Alternate explanation for implantation failure (e.g., intrauterine pathology)
研究组 & 干预措施
EMB intervention
These patients receive and endometrial biopsy
干预措施: endometrial biopsy (Procedure)
Routine care
These patient receive routine care
结局指标
主要结局
clinical pregnancy rate
时间窗: within 6 months after recruitment
Number of patients with ultrasound evidence of pregnancy divided by the number of embryo transfers
Implantation rate
时间窗: within 6 months after recruitment
Sacs seen in early ultrasound divided by the number of embryos transferred
次要结局
- ongoing pregnancy rate(within 18 months of recruitment)
- biochemical pregnancy rate(within 6 months after recruitment)
- miscarriage rate(within 18 months after recruitment)