Endometrial Scratching for Cryopreserved Embryo Transfer

Not Applicable

Terminated

• Conditions: Subfertility
• Interventions: Procedure: Endometrial injury

• Registration Number: NCT02093442
• Lead Sponsor: University of Sao Paulo

Brief Summary

Endometrial injury performed in a cycle preceding the one for embryo transfer is associated with an increased implantation and pregnancy rate when carried out during the month preceding that of ovulation induction and fresh embryo transfer. However, there is no evidence about the effect of this intervention on the transfer of cryopreserved embryos.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2014-03-18
• Study First Submitted QC: 2014-03-20
• Study First Posted: 2014-03-21
• Study Start: 2014-07
• Primary Completion: 2016-06
• Study Completion: 2016-06
• Status Verified: 2018-05
• Last Update Submitted: 2018-05-07
• Last Update Posted: 2018-05-14

Recruitment & Eligibility

• Status: TERMINATED
• Sex: Female
• Target Recruitment: 62

Inclusion Criteria

• Age > 18
• At least one cryopreserved embryo

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Exclusion Criteria

• None

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Endometrial injury	Endometrial injury	Women allocated to this group will be submitted to endometrial injury before undergoing endometrial preparation for embryo transfer.

Primary Outcome Measures

Name	Time	Method
Live birth	10 months	The complete expulsion or extraction from its mother of a product of fertilization, irrespective of the duration of the pregnancy, which, after such separation, breathes or shows any other evidence of life, such as heart beat, umbilical cord pulsation, or definite movement of voluntary muscles, irrespective of whether the umbilical cord has been cut or the placenta is attached.

Secondary Outcome Measures

Name	Time	Method
Clinical pregnancy	3 months	A pregnancy diagnosed by ultrasonographic visualization of one or more gestational sacs or definitive clinical signs of pregnancy. It includes ectopic pregnancy. Note: Multiple gestational sacs are counted as one clinical pregnancy.
Miscarriage	5 months	The spontaneous loss of a clinical pregnancy

Trial Locations

Locations (1)

Setor de Reprodução Humana - FMRP-USP; 🇧🇷 Ribeirao Preto, SP, Brazil