The Combination of Endometrial Injury and Freeze All Strategy in Women With a History of Repeated Implantation Failure.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Physiological parameter - Live birth rate
研究概览
简要总结
The investigators checked the hypothesis whether endometrial injury performed during the cycle before a frozen embryo transfer in women with RIF can improve pregnancy rates
详细描述
After a freeze all cycle, participants were divided in two groups: an intervention group (n=30), who underwent endometrial injury before the transfer, and a control group (n=30), who underwent no other intervention. The primary outcome was clinical pregnancy rate, while secondary clinical and laboratory parameters. Baseline and cycle characteristics were also compared between groups.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 25 Years 至 42 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Women with RIF under 42 years old
- •BMI 20-30
- •Normal endometrial cavity
- •FSH <15 IU/L
- •Absence of immunological or hematological disorder
排除标准
- •women over 42 years old
- •FSH>15 IU/L
- •women with chronic immunological or hematological disorder
- •stage III or IV of endometriosis
- •women with pathology concerning the endometrial cavity
- •women with a medical history of adnexectomy or oophorectomy
结局指标
主要结局
Physiological parameter - Live birth rate
时间窗: 22 weeks
The complete expulsion or extraction from a woman of a product of fertilization, after 22 completed weeks of gestational age
次要结局
- Adverse event - Miscarriage(22 weeks)
- Physiological parameter -Clinical pregnancy rate(7 weeks)
研究者
IOANNIS RIGOS
Principal Investigator
National and Kapodistrian University of Athens