Evaluation of Induced Endometrial Injury in the Subsequent IVF Cycle.
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Sterility
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
- Enrollment
- 600
- Locations
- 1
- Primary Endpoint
- Ongoing implantation rate (OIR)
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
Some studies have revealed that an induced endometrial injury could improve embryo human implantation in patients with implantation failure.
The purpose of this study is to determine whether the induced endometrial injury could be beneficial for regular patients undergoing IVF
Detailed Description
Endometrial induced injury has been suggested that could improve embryo implantation in cases of patients with recurrent implantation failure. The mechanisms that induce that improvement remain unknown. We want to analyse if the endometrial induce injury could be useful in cases of standard patients who require assisted reproductive techniques. For that purpose we will start a randomized controlled trial with the ideal background in implantation in ART, the egg donation programme.
Investigators
Carmina Vidal, MD
Obstetrics and Gynecology
Instituto Valenciano de Infertilidad, IVI VALENCIA
Eligibility Criteria
Inclusion Criteria
- •19-44 aged women
- •19-29.9 Kg/m
- •1st or 2nd fresh embryo transfer ( egg donation).
- •1 or 2 blastocysts available.
- •written agreement.
- •\> or = 6 mms endometrial thickness.
Exclusion Criteria
- •Premature ovarian failure.
- •Endometrial pathology.
- •Insufficient endometrial development.
- •Hydrosalpinx
- •Mullerian malformations.
Outcomes
Primary Outcomes
Ongoing implantation rate (OIR)
Time Frame: 12 weeks of pregnancy
Secondary Outcomes
- Live born rate (LBR)(9 months after embryo transfer)