Evaluating the effect of endometrial local injury in increasing pregnancy rate in patients undergoing ART (IVF/ICSI)
Overview
- Phase
- Phase 3
- Intervention
- Not specified
- Conditions
- Infertility.
- Sponsor
- Royan Institute
- Enrollment
- 220
- Status
- Completed
- Last Updated
- 8 years ago
Overview
Brief Summary
Implantation of the human embryo is the limiting factor in the success of invitro-fertilization and embryo transfer (IVF-ET).We wanted to find out whether creating a local injury to the endometrium in the non-transfer cycle would improve the IVF-ET outcome in the subsequent cycle. We believe that the injury created causes release of substances which help in implantation.
Study Design and Subjects: This is a randomized control study designed to evaluate the effect of local injury to the endometrium in non-transfer cycle in patients with previous failed IVF (at least =1 cycles have failed).
Patients will be randomly allotted to control and intervention group. The patients in the intervention group Pipelle endometrial sampling 19-21th day (biopsy in luteal) in the cycle prior to IVF transfer cycle.
Outcome Measures: Clinical pregnancy rate, implantation rate and ongoing pregnancy rate.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Inclusion Criteria: Previous failed In\-vitro fertilization embryo transfer cycle (at least \=1 cycles have failed); Patients who are good responders and have good quality embryos in the previous attempts; Age of patients up to 40 years.
Exclusion Criteria
- •Those with intramural fibroid distorting the endometrial cavity/sub\-mucous myoma; Those with sonographically detected hydrosalpinx; age over than 40 years old; poor responders to ovarian stimulation.
Outcomes
Primary Outcomes
Not specified