Evaluating the effect of endometrial local injury in increasing pregnancy rate in patients undergoing ART (IVF/ICSI)
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 入组人数
- 220
研究概览
简要总结
Implantation of the human embryo is the limiting factor in the success of invitro-fertilization and embryo transfer (IVF-ET).We wanted to find out whether creating a local injury to the endometrium in the non-transfer cycle would improve the IVF-ET outcome in the subsequent cycle. We believe that the injury created causes release of substances which help in implantation.
Study Design and Subjects: This is a randomized control study designed to evaluate the effect of local injury to the endometrium in non-transfer cycle in patients with previous failed IVF (at least =1 cycles have failed).
Patients will be randomly allotted to control and intervention group. The patients in the intervention group Pipelle endometrial sampling 19-21th day (biopsy in luteal) in the cycle prior to IVF transfer cycle.
Outcome Measures: Clinical pregnancy rate, implantation rate and ongoing pregnancy rate.
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 years 至 40 years（—）
- 性别
- Female
入选标准
- •Inclusion Criteria: Previous failed In-vitro fertilization embryo transfer cycle (at least =1 cycles have failed); Patients who are good responders and have good quality embryos in the previous attempts; Age of patients up to 40 years.
排除标准
- •Those with intramural fibroid distorting the endometrial cavity/sub-mucous myoma; Those with sonographically detected hydrosalpinx; age over than 40 years old; poor responders to ovarian stimulation.