Endometrial Injury May Increase the Pregnancy Rate in Patients Undergoing Intrauterine Insemination
Overview
- Phase
- Phase 3
- Intervention
- intrauterine insemination
- Conditions
- Infertility
- Sponsor
- Ain Shams Maternity Hospital
- Enrollment
- 360
- Primary Endpoint
- Chemical Pregnancy Rate
- Status
- Completed
- Last Updated
- 10 years ago
Overview
Brief Summary
The investigator suggests that local endometrial injury using pipelle catheter performed in the follicular phase (cycle day 5, 6 or 7) of the stimulation cycle may improve the pregnancy rates among patients undergoing intrauterine insemination.
Detailed Description
In a selected group of patients with repeated implantation failure, endometrial injury in the preceding cycle may improve ICSI outcome. Little is known about the efficacy of this procedure in improving intrauterine insemination outcome. Also little is known about the effect of this procedure if done in the stimulation cycle weather in ICSI or intrauterine insemination cycles.
Investigators
Ahmed Mohamed Bahaa Eldin Ahmed
lesturer in Obstetrics and Gynecology.
Ain Shams Maternity Hospital
Eligibility Criteria
Inclusion Criteria
- •18 - 38 years.
- •patent fallopian tunes.
- •mild male factor.
- •anovulation.
- •unexplained infertility.
Exclusion Criteria
- •indications for ICSI.
- •evidence of pelvic inflammatory disease.
Arms & Interventions
no endometrial injury
Ovarian stimulation combined with intrauterine insemination.
Intervention: intrauterine insemination
endometrial injury
Endometrial injury during ovarian stimulation combined with intrauterine insemination.
Intervention: endometrial injury.
endometrial injury
Endometrial injury during ovarian stimulation combined with intrauterine insemination.
Intervention: intrauterine insemination
endometrial injury
Endometrial injury during ovarian stimulation combined with intrauterine insemination.
Intervention: ovarian stimulation
no endometrial injury
Ovarian stimulation combined with intrauterine insemination.
Intervention: ovarian stimulation
Outcomes
Primary Outcomes
Chemical Pregnancy Rate
Time Frame: two weeks after intrauterine insemination
Human chorionic gonadotrophin (b-hcg) detection in serum two weeks after intrauterine insemination.
Clinical Pregnancy Rate
Time Frame: six weeks
Ultrasound detection of an intrauterine positive fetal heart pulsations