The Effectiveness of Endometrial Injury in Different Phase of Menstrual Cycle:a Prospective Controlled Clinical Study
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 400
- 试验地点
- 1
- 主要终点
- Clinical pregnancy rate
研究概览
简要总结
Many studies have demonstrated that endometrial scratch significantly increase pregnancy rate in patients undergoing in vitro fertilization and embryo transfer. However, only a limited number of studies have been conducted in frozen thawed transfer (FET) cycle. Nowadays, in FET cycles, endometrial scratch is mainly performed on two different time points: 1) luteal phase in the previous cycle; 2)early follicular phase in the current cycle. However, few studies have compared the effectiveness of those two different endometrial scratch methods performed in different timing. The aim of this study is to find the best timing of endometrial scratch in FET cycles.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •To be aged younger than 40 years old;
- •At least one period IVF-ET (fresh or thaw) has been done and not pregnant after at least one qualified blastocyst (more than 3BB) or two qualified embryos (more than II/6) have been transferred;
- •There are qualified embryos thawed and the thaw-ET period will be taken.
排除标准
- •Malformation of uterus: such as uterus uni-corns, uterus bi-corns, untreated uterus septus, etc.;
- •History of endometrial diseases: such as intrauterine adhesion, uterine cavity tuberculosis, severe dysplasia of endometrium, etc.;
- •Multiple myomata or endometrioma which causes uterus oppression;
- •Multiple and recurrent endometrial polyps;
- •Pelvic tuberculosis, endometriosis.
结局指标
主要结局
Clinical pregnancy rate
时间窗: 35 days after embryo transfer
See heart beat with ultrasonic exam.
次要结局
- Ectopic pregnancy rate(35 days after embryo transfer)
研究者
Yingpu Sun
Director of Reproductive Medical Center
The First Affiliated Hospital of Zhengzhou University