Endometrial Scratch Effect on Pregnancy Rates When Performed During the Previous Cycle of Embryo Transfer in Patients Undergoing Egg-donation IVF
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 352
- 试验地点
- 2
- 主要终点
- Positive Pregnancy Test
研究概览
简要总结
Clinical trial about the effect of endometrial scratch on pregnancy rates in patients undergoing a treatment with in-vitro fertilization with donor eggs, when doing the endometrial biopsy during the cycle prior to the embryo transfer.
详细描述
The aim of this clinical trial is to investigate whether an endometrial scratch during the cycle prior to embryo transfer cycle is effective or not in increasing pregnancy rates. Previous studies about this issue have not shown clear conclusions about the effectiveness of this method.
The endometrial scratch is a simple technique that consists in performing a mild injury to all the internal walls of the uterus with a Pipelle Cournier.
To achieve the trial objective, all participating patients are randomly divided into two groups. Once patients decide to participate in the trial, they are assigned to each group according to the randomization list:
Group A: Patients with transfer of fresh embryos after taking an endometrium biopsy during the previous cycle and then following the conventional preparation protocol.
Group B: Patients with transfer of fresh embryos with the conventional preparation protocol.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Female undergoing IVF treatment with donor eggs
排除标准
- •Severe male factor ( less tan 2 million spermatozoa per ml )
- •Uterine abnormalities
结局指标
主要结局
Positive Pregnancy Test
时间窗: 12 to 14 days after embryo transfer
Positive test (hcG\>10 UI/ml)
Clinical Pregnancy
时间窗: 5 weeks of pregnancy
Ultrasound confirmation of intrauterine pregnancy
次要结局
- Live Birth(Pregnancy beyond 24 weeks)
研究者
ALEXANDRA IZQUIERDO RODRIGUEZ
MD
Procreatec