Endometrial Injury and Single Embryo Transfer
Not Applicable
Completed
- Conditions
- Primary Infertility
- Registration Number
- NCT01851876
- Lead Sponsor
- Karadeniz Technical University
- Brief Summary
Endometrial injury increases clinical pregnancy rate in normoresponder patients undergoing long agonist protocol intracytoplasmic sperm injection cycles with single embryo transfer.
- Detailed Description
Endometrial injury means endometrial biopsy on day 3 of menstrual cycle following down regulation in an IVF patient.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 118
Inclusion Criteria
- woman age under 35 years
- history of primary infertility
- normoresponder (antral follicle count 5-10 in one ovary in early follicular phase
- having grade I or II embryos for transfer
- agree to undergo endometrial biopsy during the COH cycle. All patients were stimulated with luteal phase long protocol.
Exclusion Criteria
- endocrinopathies (including diabetes mellitus, hyperprolactinemia, Cushing's disease, and congenital adrenal hyperplasia), any systemic disease, collagen disorder, hypercholesterolemia, sickle cell anemia, and a history of neoplasm; -high risk for or history of OHSS
- using any concurrent medication (e.g., insulin-sensitizing drugs, and GnRH antagonists)
- patients who did not proceed to follicle retrieval
- severe male infertility requiring TESA/TESA
- mullerian tract anomalies
- a history of endometrial instrumentation or surgery within a month of the study
- not agree to undergo endometrial biopsy during the COH cycle.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Clinical Pregnancy Rate 4 months
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms explain endometrial injury's effect on clinical pregnancy rates in normoresponders undergoing long agonist protocol IVF cycles?
How does endometrial injury compare to standard-of-care treatments in improving clinical pregnancy outcomes for normoresponder patients in IVF cycles with single embryo transfer?
Are there specific biomarkers that can predict which normoresponder patients will benefit most from endometrial injury in long agonist protocol IVF cycles?
What are the potential adverse events associated with endometrial injury in IVF patients and how can they be managed effectively?
What combination therapies or alternative approaches have been explored alongside endometrial injury to enhance clinical pregnancy rates in normoresponder IVF patients?