Endometrial Injury May Increase the Clinical Pregnancy Rate in Normoresponders Underwent Long Agonist Protocol Intracytoplasmic Sperm Injection Cycles With Single Embryo Transfer

Karadeniz Technical University0 sites118 target enrollmentSeptember 2010

ConditionsPrimary Infertility

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Primary Infertility
Sponsor: Karadeniz Technical University
Enrollment: 118
Primary Endpoint: Clinical Pregnancy Rate
Status: Completed
Last Updated: 12 years ago

Overview Investigators Eligibility Criteria Outcomes Similar Trials

Overview

Brief Summary

Endometrial injury increases clinical pregnancy rate in normoresponder patients undergoing long agonist protocol intracytoplasmic sperm injection cycles with single embryo transfer.

Detailed Description

Endometrial injury means endometrial biopsy on day 3 of menstrual cycle following down regulation in an IVF patient.

Registry

clinicaltrials.gov

Start Date

September 2010

End Date

April 2011

Last Updated

12 years ago

Study Type

Interventional

Study Design

Parallel

Sex

Female

Investigators

Sponsor

Karadeniz Technical University

Responsible Party

Principal Investigator

Suleyman Guven

Assoc. Prof.

Karadeniz Technical University

Eligibility Criteria

Inclusion Criteria

•woman age under 35 years
•history of primary infertility
•normoresponder (antral follicle count 5-10 in one ovary in early follicular phase
•having grade I or II embryos for transfer
•agree to undergo endometrial biopsy during the COH cycle. All patients were stimulated with luteal phase long protocol.

Exclusion Criteria

•endocrinopathies (including diabetes mellitus, hyperprolactinemia, Cushing's disease, and congenital adrenal hyperplasia), any systemic disease, collagen disorder, hypercholesterolemia, sickle cell anemia, and a history of neoplasm; -high risk for or history of OHSS
•using any concurrent medication (e.g., insulin-sensitizing drugs, and GnRH antagonists)
•patients who did not proceed to follicle retrieval
•severe male infertility requiring TESA/TESA
•mullerian tract anomalies
•a history of endometrial instrumentation or surgery within a month of the study
•not agree to undergo endometrial biopsy during the COH cycle.