Randomized Prospective Study of Endometrial Injury in In Vitro Fertilization Cycles With Oocyte Donation

Centro de Infertilidad y Reproducción Humana1 site in 1 countryApril 2013

ConditionsSubfertility

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Subfertility
Sponsor: Centro de Infertilidad y Reproducción Humana
Locations: 1
Primary Endpoint: biochemical pregnancy
Status: Withdrawn
Last Updated: 8 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

This study is designed to evaluate the potential benefit in pregnancy rates produced by an endometrial scratching made in an IVF cycle prior to embryo transfer in patients with donated oocytes.

Detailed Description

This is a randomized, comparative, prospective, double Blind study. The First stage of this study consists of revising the patients medical records to identify possible candidates. Patients indicated are randomized into two groups: experimental and control. They are followed up to 12 week of pregnancy.

Registry

clinicaltrials.gov

Start Date

April 2013

End Date

January 2017

Last Updated

8 years ago

Study Type

Interventional

Study Design

Parallel

Sex

Female

Investigators

Sponsor

Centro de Infertilidad y Reproducción Humana

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Do IVF cycle with donor eggs
•Will adjust to protocol for the study.
•Have signed informed consent

Exclusion Criteria

•Clinically significant systemic disease, hypothalamic or pituitary tumors
•ovarian, uterine or breast cancer
•hormonal abnormalities and / or medical , biochemistry, hematology pathology, which might interfere with gonadotropin treatment.
•known positivity for human immunodeficiency virus (HIV), hepatitis C or B virus (HCV / HBV) of the candidate or her partner.
•Uterine Factor(submucosal fibroids, intramural fibroids\> 4 cm)
•Hydrosalpinx
•Patients receiving immune treatment
•Positive Diagnosis Thrombophilia
•preimplantation genetic diagnosis needed
•In case of using marital sperm are excluded the following patients:Altered male karyotype, Altered Meiosis in testicular biopsy, Altered FISH, sperm Fragmentation\> 45%