Impact of Endometrial Compaction on Clinical Pregnancy Rate in Frozen Embryo Transfers
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 80
- 主要终点
- clinical pregnancy rate
研究概览
简要总结
To find out if the percentage of endometrial compaction is correlated to clinical pregnancy rate in down regulated frozen embryo transfer cycle. Endometrial compaction is the change in endometrial thickness between the end of the estrogen only phase and the day of embryo transfer. In concept, the compaction of the endometrium after progesterone initiation indicates that the endometrium is responsive to progesterone and could therefore be used as a proxy for endometrial receptivity predictability of FET cycle outcome
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 35 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Women undergoing down regulated cycles frozen embryo transfer.
- •Women at age group 20-35 years old.
- •Day 5 embryos will be transferred.
排除标准
- •Chromosomal abnormality in either partner (As this could lead to cycle cancellation).
- •Uterine malformation or any intrauterine condition affecting the pregnancy outcomes of FET, such as endometrial polyps, uterine cavity adhesion, history of endometrial tuberculosis, hydrosalpinx with a reflux into uterine cavity (As the might not be candidates for IVF cycle till correction).
- •Recurrent implantation failure, defined as 2 or more previous failed trials (Other confounding factors might of present which could affect the results).
- •Cycles of patients with persistent endometrial thickness <7mm during treatment protocol (Due to cycled cancelation).
结局指标
主要结局
clinical pregnancy rate
时间窗: 3-4 wks after ET
Clinical pregnancy rate, determined by visualizing a viable embryo within the uterine cavity by ultrasound 3-4 weeks after ET, in patients with endometrial compaction in down regulated FET cycles in comparison to non endometrial compaction.
次要结局
- Percentage of change of endometrial thickness between the end of estrogen administration only phase and the day of embryo transfer.(3-4 wks after ET)
- Chemical pregnancy rates, detected by positive hCG test in the absence of pregnancy findings on TVUS(3-4 wks after ET)
- Number of estrogen administration days(10 days before ET)