The Impact of Endometrial Compaction on Ongoing Pregnancy Rate in Assisted Reproductive Technology Cycles : Prospective Cohort Study
试验速览
- 阶段
- 不适用
- 入组人数
- 145
- 试验地点
- 1
- 主要终点
- Ongoing pregnancy rate
研究概览
简要总结
To record the dynamic change of endometrial thickness (Day of embryo transfer Versus. Day of ovulation trigger administration in case of fresh cycles or end of estrogen phase in frozen cycles), and to investigate the impact of endometrial thickness change on pregnancy outcomes
详细描述
Clinical pregnancy rate in IVF cycles depends on embryo quality and endometrial receptivity . It is challenging to assess endometrial receptivity. Measuring endometrial thickness by ultrasonography is a simple , noninvasive and accurate method to do so. Many studies have implicated endometrial thickness and pattern as prognostic parameters for successful outcomes in IVF-ET.
Some studies have suggested a minimal thickness for a successful pregnancy to occur, while others have reported adverse effects of increased endometrial thickness above which pregnancy is unlikely to occur.
Now there is a novel hypothesis that not only the initial endometrial thickness can affect implantation rate and clinical pregnancy rate ,but also the decrease in endometrial thickness in the time interval between the ovulation triggering and the embryo transfer or what is called endometrial compaction increases the implantation and clinical pregnancy rate
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •• Infertile women aged 18 years to 40 years undergoing IVF/ ICSI for any indication.
排除标准
- •• History of recurrent pregnancy loss (≥ 2 spontaneous abortions) and/or history of recurrent (≥ 2) ICSI failure after embryo transfer.
- •Uterine malformations.
- •Uncorrected hydrosalpinx.
- •Intrauterine conditions affecting pregnancy outcomes such as ( intrauterine adhesions, fibroids, polyps).
- •Any previous hysteroscopic surgery eg. Metroplasty or hysteroscopic myomectomy or uterine surgeries involving the endometrium eg. myomectomy during which uterine cavity was opened.
- •History suggesting endometritis.
- •Use of hCG for endometrial preparation or luteal phase support.
- •Poor quality embryos( according to Istanbul consensus workshop on embryo assessment )
结局指标
主要结局
Ongoing pregnancy rate
时间窗: 12 weeks after embryo transfer if hCG tested positive
rate of ongoing pregnancy in patients who have endometrial compaction
次要结局
未报告次要终点
研究者
Ayman Ahmad Abdelraof Ahmad Askar
assisstant lecturer
Assiut University