Endometrial Hysteroscopy and Curettage Prior to Embryo Transfer
Trial Snapshot
- Phase
- Not Applicable
- Enrollment
- 90
- Locations
- 2
- Primary Endpoint
- Implantation rate
Study Overview
Brief Summary
Studies have shown that endometrial sampling in the month prior to embryo transfer may increase pregnancy rates. We wish to test this hypothesis by performing a hysteroscopy and curettage in the month proceeding embryo transfer during IVF, IVF/ICSI or Frozen/Thawed cycles.
Detailed Description
It has been suggested that local injury to the endometrium doubles the rate of implantation and successful pregnancies in IVF patients.
Purpose
- To determine whether performing curettage the month prior to embryo transfer (ET) increases the chance of embryo implantation.
- To study molecular attributes of the endometrium taken at curettage and to compare them to those cycles resulting in pregnancy and those which do not result in pregnancy.
Samples will be grown as primary culture in the research laboratory and possible molecular markers and attachment assays for endometrial receptivity will be studied.
Patient selection: Patients undergoing IVF or IVF-ICSI at Ha'Emek medical center/ IVF unit. Woman over 35 years of age will be excluded since implantation failure is more likely to be due to genetic, chromosomal or cytoplasmic aberrations in their oocytes.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 35 Years (Adult)
- Sex
- Female
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Informed consent
- •In-vitro fertilization candidate
- •Normal blood coagulation
Exclusion Criteria
- •Anemia (hemoglobin under 10 mg/dl)
- •Abnormal maternal karyotype
- •Thrombocytopenia under 140,000
- •Any contraindication to hysteroscopy or in-vitro fertilization
Outcomes
Primary Outcomes
Implantation rate
Pregnancy rate
Endometrial receptivity
Secondary Outcomes
No secondary outcomes reported