MedPath

Dose-ranging Study to Evaluate the Efficacy, Safety, and Tolerability of AMG 133 in Adult Subjects With Overweight or Obesity, With or Without Type 2 Diabetes Mellitus

Phase 2
Active, not recruiting
Conditions
Type 2 Diabetes Mellitus
Overweight
Obesity
Interventions
Registration Number
NCT05669599
Lead Sponsor
Amgen
Brief Summary

The study aims to compare and assess the dose response of 3 selected doses of maridebart cafraglutide compared with placebo, on inducing and maintaining weight loss from baseline at Week 52 in participants with overweight or obesity without diabetes mellitus (Cohort A) and in participants with overweight or obesity with Type 2 diabetes mellitus (Cohort B).

Detailed Description

Not available

Recruitment & Eligibility

Status
ACTIVE_NOT_RECRUITING
Sex
All
Target Recruitment
592
Inclusion Criteria
  • Age ≥18 years at the time of signing informed consent.
  • BMI ≥30 kg/m^2, or ≥27 kg/m^2 and previous diagnosis with at least one of the following comorbidities: hypertension, dyslipidemia, obstructive sleep apnea, cardiovascular disease.
  • For participants in cohort B only, HbA1c ≥ 7% and ≤ 10% (53 to 86 mmol/mol) at screening with an established diagnosis of type 2 diabetes mellitus for ≥ 180 days prior to screening and either treated with diet and exercise alone or on stable (at least 90 days prior to screening) treatment with metformin, a sulfonylurea, or a sodium-glucose cotransporter 2 (SGLT2) inhibitor as monotherapy or combination therapy, per approved local label.
  • History of at least one unsuccessful dietary effort to lose body weight.
Exclusion Criteria
  • Change in body weight greater than 5 kg within 3 months prior to screening.
  • Obesity induced by other endocrinologic disorders.
  • History of pancreatitis.
  • Family or personal history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 (MEN-2).
  • History of major depressive disorder within the last 2 years.
  • Any lifetime history of other major psychiatric disorder or suicide attempt.

Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Arm && Interventions
GroupInterventionDescription
Cohort A: Maridebart CafraglutidePlaceboPart 1: Cohort A will consist of participants without a diagnosis of type 1 or type 2 diabetes mellitus. Participants will be randomized to receive maridebart cafraglutide or placebo in 1 of 7 dose cohorts. Participants will then have the option to begin part 2 if they meet the entry criteria. Part 2: Participants that continue into part 2 will be re-randomized to receive maridebart cafraglutide or Placebo in 1 of 4 dose cohorts.
Cohort A: PlaceboPlaceboPart 1: Cohort A will consist of participants without a diagnosis of type 1 or type 2 diabetes mellitus. Participants will be randomized to receive maridebart cafraglutide or placebo in 1 of 7 dose cohorts . Participants will then have the option to begin part 2 if they meet the entry criteria. Part 2: Participants that continue into part 2 will be re-randomized to receive maridebart cafraglutide or Placebo in 1 of 4 dose cohorts.
Cohort B: Maridebart CafraglutidePlaceboPart 1: Cohort B will consist of participants with a diagnosis of type 2 diabetes mellitus. Participants will be randomized to receive maridebart cafraglutide or placebo in 1 of 4 dose cohorts. Participants will then have the option to begin part 2 if they meet the entry criteria. Part 2: Participants that continue into part 2 will be re-randomized to receive maridebart cafraglutide or Placebo in 1 of 4 dose cohorts.
Cohort B: PlaceboPlaceboPart 1: Cohort B will consist of participants with a diagnosis of type 2 diabetes mellitus. Participants will be randomized to receive maridebart cafraglutide or placebo in 1 of 4 dose cohorts. Participants will then have the option to begin part 2 if they meet the entry criteria. Part 2: Participants that continue into part 2 will be re-randomized to receive maridebart cafraglutide or Placebo in 1 of 4 dose cohorts.
Cohort A: Maridebart CafraglutideMaridebart CafraglutidePart 1: Cohort A will consist of participants without a diagnosis of type 1 or type 2 diabetes mellitus. Participants will be randomized to receive maridebart cafraglutide or placebo in 1 of 7 dose cohorts. Participants will then have the option to begin part 2 if they meet the entry criteria. Part 2: Participants that continue into part 2 will be re-randomized to receive maridebart cafraglutide or Placebo in 1 of 4 dose cohorts.
Cohort B: PlaceboMaridebart CafraglutidePart 1: Cohort B will consist of participants with a diagnosis of type 2 diabetes mellitus. Participants will be randomized to receive maridebart cafraglutide or placebo in 1 of 4 dose cohorts. Participants will then have the option to begin part 2 if they meet the entry criteria. Part 2: Participants that continue into part 2 will be re-randomized to receive maridebart cafraglutide or Placebo in 1 of 4 dose cohorts.
Cohort A: PlaceboMaridebart CafraglutidePart 1: Cohort A will consist of participants without a diagnosis of type 1 or type 2 diabetes mellitus. Participants will be randomized to receive maridebart cafraglutide or placebo in 1 of 7 dose cohorts . Participants will then have the option to begin part 2 if they meet the entry criteria. Part 2: Participants that continue into part 2 will be re-randomized to receive maridebart cafraglutide or Placebo in 1 of 4 dose cohorts.
Cohort B: Maridebart CafraglutideMaridebart CafraglutidePart 1: Cohort B will consist of participants with a diagnosis of type 2 diabetes mellitus. Participants will be randomized to receive maridebart cafraglutide or placebo in 1 of 4 dose cohorts. Participants will then have the option to begin part 2 if they meet the entry criteria. Part 2: Participants that continue into part 2 will be re-randomized to receive maridebart cafraglutide or Placebo in 1 of 4 dose cohorts.
Primary Outcome Measures
NameTimeMethod
Percent Change From Baseline to Week 52 in Body WeightBaseline and Week 52
Secondary Outcome Measures
NameTimeMethod
Change from Baseline to Week 52 in Diastolic Blood Pressure (DBP)Baseline and Week 52
Percent Change From Baseline to Week 52 in High-sensitivity C-reactive Protein (hs-CRP)Baseline and Week 52
Percent Change From Baseline in Low-density Lipoprotein Cholesterol (LDL-C)Baseline and Week 52
Achievement of ≥ 20% Reduction in Body Weight From Baseline at Week 52Baseline and Week 52
Change from Baseline to Week 52 in Hemoglobin A1c (HbA1c)Baseline and Week 52
Maximum Observed Plasma Concentration (Cmax) of maridebart cafraglutideUp to Week 64
Area Under the Concentration-time Curve (AUC) of maridebart cafraglutideUp to Week 64
Percent Change From Baseline in Total CholesterolBaseline and Week 52
Percent Change From Baseline in non-HDL-CBaseline and Week 52
Percentage of Participants Achieving ≥ 10% Reduction in Body Weight From Baseline at Week 52Baseline and Week 52
Achievement of ≥ 15% Reduction in Body Weight From Baseline at Week 52Baseline and Week 52
Change from Baseline to Week 52 in Systolic Blood Pressure (SBP)Baseline and Week 52
Change from Baseline to Week 52 in Body Mass Index (BMI)Baseline and Week 52
Change from Baseline to Week 52 in Fasting Plasma GlucoseBaseline and Week 52
Change from Baseline to Week 52 in Waist CircumferenceBaseline and Week 52
Percent Change From Baseline in Very-low-density Lipoprotein Cholesterol (VLDL-C)Baseline and Week 52
Percentage of Participants Achieving ≥ 5% Reduction in Body Weight From Baseline at Week 52Baseline and Week 52
Change from Baseline to Week 52 in Fasting Serum InsulinBaseline and Week 52
Change from Baseline to Week 52 in Homeostasis Model Assessment for Insulin Resistance (HOMA2-IR)Baseline and Week 52
Change from Baseline to Week 52 in Homeostasis Model Assessment for Steady State Beta Cell Function (HOMA2-%B)Baseline and Week 52
Change from Baseline to Week 52 in Body WeightBaseline and Week 52
Change from Baseline to Week 52 in Body Fat Mass Using Dual-energy X-ray Absorptiometry (DEXA)Baseline and Week 52

Analyzed in a subset of participants.

Change from Baseline to Week 52 in Lean Body Mass Using DEXABaseline and Week 52

Analyzed in a subset of participants.

Percent Change From Baseline in High-density Lipoprotein Cholesterol (HDL-C)Baseline and Week 52
Percent Change From Baseline in TriglyceridesBaseline and Week 52
Percent Change From Baseline in Free Fatty Acids (FFA)Baseline and Week 52

Trial Locations

Locations (78)

Progressive Medical Research

🇺🇸

Port Orange, Florida, United States

Diablo Clinical Research

🇺🇸

Walnut Creek, California, United States

Research Innovations LLC dba Internal Medicine Care Inc

🇺🇸

Beavercreek, Ohio, United States

Lucas Research

🇺🇸

Morehead City, North Carolina, United States

Headlands Research Brownsville

🇺🇸

Brownsville, Texas, United States

University of Calgary

🇨🇦

Calgary, Alberta, Canada

Universitaetsmedizin Leipzig

🇩🇪

Leipzig, Germany

Mikannohana Clinic, Diabetes, Endocrinology and Metabolism

🇯🇵

Matsuyama-shi, Ehime, Japan

Wellness Tenjin Clinic

🇯🇵

Fukuoka-shi, Fukuoka, Japan

Mazda Hospital of Mazda Motor Corporation

🇯🇵

Aki-gun, Hiroshima, Japan

Nihonbashi Sakura Clinic

🇯🇵

Chuo-ku, Tokyo, Japan

Seoul National University Bundang Hospital

🇰🇷

Seongnam-si, Gyeonggi-do, Korea, Republic of

Gachon University Gil Medical Center

🇰🇷

Incheon, Korea, Republic of

Dongguk University Ilsan Hospital

🇰🇷

Goyang-si, Gyeonggi-do, Korea, Republic of

Centrum Badan Klinicznych PI-House Spzoo

🇵🇱

Gdansk, Poland

National Cheng Kung University Hospital

🇨🇳

Tainan, Taiwan

Clinical Medical and Analytical eXellence CMAX

🇦🇺

Adelaide, South Australia, Australia

University of Chicago

🇺🇸

Chicago, Illinois, United States

Great Lakes Clinical Trials

🇺🇸

Chicago, Illinois, United States

Alliance for Multispecialty Research Norman

🇺🇸

Norman, Oklahoma, United States

Centricity Research Brampton Endocrinology

🇨🇦

Brampton, Ontario, Canada

Pinnacle Clinical Research

🇺🇸

San Antonio, Texas, United States

Clinical Trials of Texas

🇺🇸

San Antonio, Texas, United States

Diabetes and Glandular Disease Clinic

🇺🇸

San Antonio, Texas, United States

Texas Diabetes Institute

🇺🇸

San Antonio, Texas, United States

East-West Medical Research

🇺🇸

Honolulu, Hawaii, United States

Alliance for Multispecialty Research Mobile

🇺🇸

Mobile, Alabama, United States

Foothills Research Center

🇺🇸

Phoenix, Arizona, United States

Ark Clinical Research- Tustin

🇺🇸

Tustin, California, United States

HonorHealth

🇺🇸

Scottsdale, Arizona, United States

Ark Clinical Research- Long Beach

🇺🇸

Long Beach, California, United States

Alliance for Multispecialty Research Miami

🇺🇸

Coral Gables, Florida, United States

Alliance for Multispecialty Research Newton

🇺🇸

Newton, Kansas, United States

StudyMetrix Research

🇺🇸

Saint Peters, Missouri, United States

State University of New York Upstate Medical University

🇺🇸

Syracuse, New York, United States

The Christ Hospital

🇺🇸

Cincinnati, Ohio, United States

PanAmerican Clinical Research LLC

🇺🇸

Brownsville, Texas, United States

Royal Prince Alfred Hospital (RPAH) Clinic

🇦🇺

Camperdown, New South Wales, Australia

St Vincents Hospital Melbourne

🇦🇺

Fitzroy, Victoria, Australia

Monash Medical Centre

🇦🇺

Clayton, Victoria, Australia

Baker Heart and Diabetes Institute

🇦🇺

Melbourne, Victoria, Australia

Clinique des Maladies Lipidiques de Quebec Incorporated

🇨🇦

Quebec, Canada

Institut Universitaire de cardiologie et de pneumologie de Quebec

🇨🇦

Quebec, Canada

Centricity Research Vaughan Endocrinology

🇨🇦

Concord, Ontario, Canada

Endokrinologicky ustav

🇨🇿

Praha 1, Czechia

Institut klinicke a experimentalni mediciny

🇨🇿

Praha 4, Czechia

Vseobecna fakultni nemocnice v Praze

🇨🇿

Praha 2, Czechia

Charite - Universitaetsmedizin Berlin, Campus Mitte

🇩🇪

Berlin, Germany

Diabeteszentrum Hamburg West

🇩🇪

Hamburg, Germany

Budapesti Szent Ferenc Korhaz

🇭🇺

Budapest, Hungary

Pecsi Tudomanyegyetem Klinikai Kozpont

🇭🇺

Pecs, Hungary

Matsunami Health Promotion Clinic

🇯🇵

Hashima-gun, Gifu, Japan

Nishiyamado Keiwa Hospital

🇯🇵

Naka-shi, Ibaraki, Japan

MIH Clinic Yoyogi

🇯🇵

Shibuya-ku, Tokyo, Japan

Shiraiwa Medical Clinic

🇯🇵

Kashiwara-shi, Osaka, Japan

Kangbuk Samsung Hospital

🇰🇷

Seoul, Korea, Republic of

AthleticoMed

🇵🇱

Bydgoszcz, Poland

Centrum Terapii Wspolczesnej

🇵🇱

Lodz, Poland

AppleTreeClinics Network Spzoo

🇵🇱

Lodz, Poland

Clinical Best Solutions Sp zoo Spolka Komandytowa

🇵🇱

Lublin, Poland

Hospital Clinico Universitario Virgen de la Victoria

🇪🇸

Malaga, Andalucía, Spain

Hospital Vithas Sevilla

🇪🇸

Castilleja de la Cuesta, Andalucía, Spain

Migre Polskie Centrum Leczenia Migreny Anna Gryglas-Dworak

🇵🇱

Wroclaw, Poland

Hospital Universitario Arnau de Vilanova Lleida

🇪🇸

Lleida, Cataluña, Spain

Kaohsiung Medical University Chung-Ho Memorial Hospital

🇨🇳

Kaohsiung, Taiwan

Complexo Hospitalario Universitario A Coruña

🇪🇸

A Coruña, Galicia, Spain

National Taiwan University Hospital

🇨🇳

Taipei, Taiwan

Orange County Research Center

🇺🇸

Tustin, California, United States

Austin Health, Heidelberg Repatriation Hospital

🇦🇺

Heidelberg Heights, Victoria, Australia

Prince of Wales Hospital

🇭🇰

Shatin, New Territories, Hong Kong

CRU Hungary Kft

🇭🇺

Encs, Hungary

Medical Care LLC

🇺🇸

Elizabethton, Tennessee, United States

Nakakinen Clinic

🇯🇵

Naka-shi, Ibaraki, Japan

China Medical University Hospital

🇨🇳

Taichung, Taiwan

Clinexpert Kft

🇭🇺

Budapest, Hungary

Louisville Metabolic and Atherosclerosis Research Center

🇺🇸

Louisville, Kentucky, United States

Alliance for Multispecialty Research Kansas City

🇺🇸

Kansas City, Missouri, United States

Tandem Clinical Research - Marrero

🇺🇸

Marrero, Louisiana, United States

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